Production of O-GlcNAc Modified Recombinant Tau in E. coli and Detection of Ser400 O-GlcNAc Tau In Vivo.
Sign Up to like & getrecommendations! Published in 2017 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-6598-4_13
Abstract: Assembly of the microtubule-associated protein tau (tau) into paired helical filaments that ultimately give rise to neurofibrillary tangles (NFTs) makes up one half of the two hallmark pathologies of Alzheimer's disease (AD). Tau has been… read more here.
Keywords: glcnac; tau; ser400; recombinant tau ... See more keywords
Keratan Sulphate in the Tumour Environment.
Sign Up to like & getrecommendations! Published in 2020 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-3-030-40146-7_2
Abstract: Keratan sulphate (KS) is a bioactive glycosaminoglycan (GAG) of some complexity composed of the repeat disaccharide D-galactose β1→4 glycosidically linked to N-acetyl glucosamine. During the biosynthesis of KS, a family of glycosyltransferase and sulphotransferase enzymes… read more here.
Keywords: glcnac; chain; keratan sulphate; biology ... See more keywords
Erratum to: O-GlcNAc Glycosylation of nNOS Promotes Neuronal Apoptosis Following Glutamate Excitotoxicity
Sign Up to like & getrecommendations! Published in 2017 at "Cellular and Molecular Neurobiology"
DOI: 10.1007/s10571-017-0495-z
Abstract: Ischemic stroke is a dominant health problem with extremely high rates of mortality and disability. The main mechanism of neuronal injury after stroke is excitotoxicity, during which the activation of neuronal nitric oxide synthase (nNOS)… read more here.
Keywords: glcnac; glcnacylation nnos; apoptosis; excitotoxicity ... See more keywords
O-GlcNAcylation in women’s cancers: breast, endometrial and ovarian
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Bioenergetics and Biomembranes"
DOI: 10.1007/s10863-017-9730-z
Abstract: O-GlcNAcylation is emerging as a critical regulatory post-translational modification, impacting proteins that regulate cell division, apoptosis, metabolism, cell signaling, and transcription. O-GlcNAc also affects biological homeostasis by integrating information coming from the environment, such as… read more here.
Keywords: glcnac; breast endometrial; glcnacylation; cancers breast ... See more keywords
O-GlcNAc in cancer: An Oncometabolism-fueled vicious cycle
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Bioenergetics and Biomembranes"
DOI: 10.1007/s10863-018-9751-2
Abstract: Cancer cells exhibit unregulated growth, altered metabolism, enhanced metastatic potential and altered cell surface glycans. Fueled by oncometabolism and elevated uptake of glucose and glutamine, the hexosamine biosynthetic pathway (HBP) sustains glycosylation in the endomembrane… read more here.
Keywords: glcnac; oncometabolism; glcnacylation; cycle ... See more keywords
O-GlcNAc cycling in the developing, adult and geriatric brain
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Bioenergetics and Biomembranes"
DOI: 10.1007/s10863-018-9760-1
Abstract: Hundreds of proteins in the nervous system are modified by the monosaccharide O-GlcNAc. A single protein is often O-GlcNAcylated on several amino acids and the modification of a single site can play a crucial role… read more here.
Keywords: glcnac; geriatric brain; adult geriatric; developing adult ... See more keywords
O-GlcNAc cycling mediates energy balance by regulating caloric memory
Sign Up to like & getrecommendations! Published in 2021 at "Appetite"
DOI: 10.1016/j.appet.2021.105320
Abstract: Caloric need has long been thought a major driver of appetite. However, it is unclear whether caloric need regulates appetite in environments offered by many societies today where there is no shortage of food. Here… read more here.
Keywords: glcnac; caloric memory; energy balance; energy ... See more keywords
Molecular mechanisms regulating O-linked N-acetylglucosamine (O-GlcNAc)-processing enzymes.
Sign Up to like & getrecommendations! Published in 2019 at "Current opinion in chemical biology"
DOI: 10.1016/j.cbpa.2019.09.001
Abstract: The post-translational modification of proteins by O-linked N-acetylglucosamine (O-GlcNAc) dynamically programmes cellular physiology to maintain homoeostasis and tailor biochemical pathways to meet context-dependent cellular needs. Despite diverse roles of played by O-GlcNAc, only two enzymes… read more here.
Keywords: glcnac; linked acetylglucosamine; mechanisms regulating; acetylglucosamine glcnac ... See more keywords
Detecting and Imaging O-GlcNAc Sites Using Glycosyltransferases: A Systematic Approach to Study O-GlcNAc.
Sign Up to like & getrecommendations! Published in 2018 at "Cell chemical biology"
DOI: 10.1016/j.chembiol.2018.07.007
Abstract: O-GlcNAcylation is a reversible serine/threonine glycosylation for regulating protein activity and availability inside cells. In a given protein, O-GlcNAcylated and unoccupied O-linked β-N-acetylglucosamine (O-GlcNAc) sites are referred to as closed and open sites, respectively. The… read more here.
Keywords: glcnac; systematic approach; approach study; glcnac sites ... See more keywords
Expression and degradation patterns of chitinase purified from Xuehuali (Pyrus bretschneiderilia) pollen.
Sign Up to like & getrecommendations! Published in 2018 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2017.09.010
Abstract: The present study investigated the expression pattern of chitinase in Xuehuali (Pyrus bretschneiderilia) pollen, as well as its subsequent degradation. The chitinase was purified and collected using chitin affinity column chromatography with regenerated chitin. After… read more here.
Keywords: glcnac; xuehuali pyrus; pyrus bretschneiderilia; glcnac glcnac ... See more keywords
Establishment of a five-enzyme cell-free cascade for the synthesis of uridine diphosphate N-acetylglucosamine.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of biotechnology"
DOI: 10.1016/j.jbiotec.2018.07.027
Abstract: In spite of huge endeavors in cell line engineering to produce glycoproteins with desired and uniform glycoforms, it is still not possible in vivo. Alternatively, in vitro glycoengineering can be used for the modification of… read more here.
Keywords: glcnac; acetylglucosamine; cell free; enzyme ... See more keywords