O-GlcNAc cycling in the developing, adult and geriatric brain
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Bioenergetics and Biomembranes"
DOI: 10.1007/s10863-018-9760-1
Abstract: Hundreds of proteins in the nervous system are modified by the monosaccharide O-GlcNAc. A single protein is often O-GlcNAcylated on several amino acids and the modification of a single site can play a crucial role… read more here.
Keywords: glcnac; geriatric brain; adult geriatric; developing adult ... See more keywords
O-GlcNAc cycling and the regulation of nucleocytoplasmic dynamics.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical Society transactions"
DOI: 10.1042/bst20160171
Abstract: The dynamic carbohydrate post-translational modification (PTM) O-linked β-N-acetyl glucosamine (O-GlcNAc) is found on thousands of proteins throughout the nucleus and cytoplasm, and rivals phosphorylation in terms of the number of substrates and pathways influenced. O-GlcNAc… read more here.
Keywords: glcnac; cycling regulation; nucleocytoplasmic dynamics; regulation nucleocytoplasmic ... See more keywords
The Emerging Roles of Protein Interactions with O-GlcNAc Cycling Enzymes in Cancer
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DOI: 10.3390/cancers14205135
Abstract: Simple Summary Dynamic O-GlcNAc modification regulates the functions of proteins in a broad range of cellular processes. Dysregulation of the sole enzymes responsible for O-GlcNAc cycling, O-GlcNAc transferase (OGT) and O-GlcNAcase (OGA), and the associated… read more here.
Keywords: ogt oga; glcnac cycling; emerging roles; protein interactions ... See more keywords