The New Chemical Reporter 6-Alkynyl-6-deoxy-GlcNAc Reveals O-GlcNAc Modification of the Apoptotic Caspases That Can Block the Cleavage/Activation of Caspase-8.
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DOI: 10.1021/jacs.7b02213
Abstract: O-GlcNAc modification (O-GlcNAcylation) is required for survival in mammalian cells. Genetic and biochemical experiments have found that increased modification inhibits apoptosis in tissues and cell culture and that lowering O-GlcNAcylation induces cell death. However, the… read more here.
Keywords: glcnac; glcnac modification; glcnacylation; chemical reporter ... See more keywords
O-GlcNAc modification of small heat shock proteins enhances their anti-amyloid chaperone activity
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DOI: 10.1038/s41557-021-00648-8
Abstract: A major role for the intracellular post-translational modification O-GlcNAc appears to be the inhibition of protein aggregation. Most of the previous studies in this area focused on O-GlcNAc modification of the amyloid-forming proteins themselves. Here… read more here.
Keywords: glcnac; glcnac modification; small heat; chemistry ... See more keywords
O-GlcNAc modification of eIF4GI acts as a translational switch in heat shock response
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DOI: 10.1038/s41589-018-0120-6
Abstract: Heat shock response (HSR) is an ancient signaling pathway leading to thermoprotection of nearly all living organisms. Emerging evidence suggests that intracellular O-linked β-N-acetylglucosamine (O-GlcNAc) serves as a molecular ‘thermometer’ by reporting ambient temperature fluctuations.… read more here.
Keywords: glcnac modification; eif4gi; heat shock; stress ... See more keywords
O-Linked β-N-acetylglucosamine (O-GlcNAc) modification: a new pathway to decode pathogenesis of diabetic retinopathy.
Sign Up to like & getrecommendations! Published in 2018 at "Clinical science"
DOI: 10.1042/cs20171454
Abstract: The incidence of diabetes continues to rise among all ages and ethnic groups worldwide. Diabetic retinopathy (DR) is a complication of diabetes that affects the retinal neurovasculature causing serious vision problems, including blindness. Its pathogenesis… read more here.
Keywords: glcnac modification; diabetic retinopathy; pathogenesis; pathway ... See more keywords
A Genetic Model to Study Increased Hexosamine Biosynthetic Flux
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DOI: 10.1210/en.2017-00359
Abstract: Recently, we identified harvest moon (hmn), a fully penetrant and expressive recessive zebrafish mutant with hepatic steatosis. Larvae showed increased triacylglycerol in the absence of other obvious defects. When we attempted to raise these otherwise… read more here.
Keywords: hexosamine biosynthetic; genetic model; glcnac modification;
O-GlcNAc Modification and Its Role in Diabetic Retinopathy
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DOI: 10.3390/metabo12080725
Abstract: Diabetic retinopathy (DR) is a leading complication in type 1 and type 2 diabetes and has emerged as a significant health problem. Currently, there are no effective therapeutic strategies owing to its inconspicuous early lesions… read more here.
Keywords: modification; glcnac modification; modification role; diabetic retinopathy ... See more keywords