O‐GlcNAc Transferase: Structural Characteristics, Catalytic Mechanism and Small‐Molecule Inhibitors
Sign Up to like & getrecommendations! Published in 2020 at "ChemBioChem"
DOI: 10.1002/cbic.202000194
Abstract: Modifications of nuclear and cytoplasmic proteins with a single sugar, N‐acetylglucosamine (GlcNAc), play roles in a wide variety of fundamental cellular processes, and aberrant O‐GlcNAc profiles are associated with pathological progression of several chronic diseases.… read more here.
Keywords: glcnac transferase; catalytic mechanism; structural characteristics; transferase structural ... See more keywords
High Glucose Inhibits O‐GlcNAc Transferase Translocation in Early Osteoblast Differentiation by Altering Protein Phosphatase 2A Activity
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.31524
Abstract: Our previous study revealed a link between O‐GlcNAc transferase (OGT) localization and protein phosphatase 2A (PP2A) activity in osteoblast. Given the association of PP2A downregulation with osteoblast differentiation, we hypothesized that OGT localization changes during… read more here.
Keywords: differentiation; glcnac transferase; osteoblast differentiation; ogt localization ... See more keywords
O‐GlcNAc transferase is required to maintain satellite cell function
Sign Up to like & getrecommendations! Published in 2021 at "STEM CELLS"
DOI: 10.1002/stem.3361
Abstract: O‐GlcNAcylation is a posttranslational modification considered to be a nutrient sensor that reports nutrient scarcity or surplus. Although O‐GlcNAcylation exists in a wide range of cells and/or tissues, its functional role in muscle satellite cells… read more here.
Keywords: glcnac transferase; muscle; glcnacylation; scs ... See more keywords
A lable-free SPR biosensor based on one peptide sequence with three recognition sites for O-GlcNAc transferase detection.
Sign Up to like & getrecommendations! Published in 2021 at "Talanta"
DOI: 10.1016/j.talanta.2020.121664
Abstract: Abnormal O-linked N-acetylglucosamine (O-GlcNAc) concentrations have been associated with many diseases, but the lack of accurate detection method limited O-GlcNAc to be used as a biomarker in clinical diagnosis. Then O-GlcNAc transferase (OGT) has drawn… read more here.
Keywords: ogt detection; glcnac transferase; peptide; spr biosensor ... See more keywords
Catalytic Promiscuity of O-GlcNAc Transferase Enables Unexpected Metabolic Engineering of Cytoplasmic Proteins with 2-Azido-2-deoxy-glucose.
Sign Up to like & getrecommendations! Published in 2017 at "ACS chemical biology"
DOI: 10.1021/acschembio.6b00876
Abstract: O-GlcNAc transferase (OGT) catalyzes the installation of N-acetylglucosamine (GlcNAc) O-linked to nucleocytoplasmic proteins (O-GlcNAc) within multicellular eukaryotes. OGT shows surprising tolerance for structural changes in the sugar component of its nucleotide sugar donor substrate, uridine… read more here.
Keywords: glcnac; azido deoxy; glcnac transferase; deoxy glucose ... See more keywords
Aspartate residues far from the active site drive O-GlcNAc transferase substrate selection.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.9b06061
Abstract: O-GlcNAc is an abundant post-translational modification found on nuclear and cytoplasmic proteins in all metazoans. This modification regulates a wide variety of cellular processes, and elevated O-GlcNAc levels have been implicated in cancer progression. A… read more here.
Keywords: glcnac; aspartate residues; substrate selection; glcnac transferase ... See more keywords
Electrophilic probes for deciphering substrate recognition by O-GlcNAc transferase
Sign Up to like & getrecommendations! Published in 2017 at "Nature chemical biology"
DOI: 10.1038/nchembio.2494
Abstract: O-linked β-N-acetylglucosamine (O-GlcNAc) transferase (OGT) is an essential human glycosyltransferase that adds O-GlcNAc modifications on numerous proteins. However, little is known about how OGT recognizes various protein substrates. Here we report GlcNAc electrophilic probes (GEPs)… read more here.
Keywords: recognition; electrophilic probes; substrate recognition; glcnac transferase ... See more keywords
O-GlcNAc transferase regulates glioblastoma acetate metabolism via regulation of CDK5-dependent ACSS2 phosphorylation
Sign Up to like & getrecommendations! Published in 2022 at "Oncogene"
DOI: 10.1038/s41388-022-02237-6
Abstract: Glioblastomas (GBMs) preferentially generate acetyl-CoA from acetate as a fuel source to promote tumor growth. O-GlcNAcylation has been shown to be elevated by increasing O-GlcNAc transferase (OGT) in many cancers and reduced O-GlcNAcylation can block… read more here.
Keywords: glcnac transferase; acss2 ser; phosphorylation; growth ... See more keywords
O-GlcNAc transferase influences the progression of degenerative cartilage disease in lumbar facet joint osteoarthritis through FoxO1 and EGR1
Sign Up to like & getrecommendations! Published in 2025 at "Cell Death Discovery"
DOI: 10.1038/s41420-025-02732-1
Abstract: This study aimed to investigate the role of the O-GlcNAc transferase (OGT)/Forkhead Box O1 (FoxO1) signaling axis in age-induced facet joint osteoarthritis (FJOA) and its impact on chondrocyte homeostasis. Using a mouse model, the effects… read more here.
Keywords: facet joint; glcnac transferase; progression; foxo1 ... See more keywords
Inhibition of O-GlcNAc transferase (OGT) by peptidic hybrids.
Sign Up to like & getrecommendations! Published in 2018 at "MedChemComm"
DOI: 10.1039/c8md00115d
Abstract: O-GlcNAc transferase (OGT) attaches a GlcNAc moiety on specific substrate proteins using UDP-GlcNAc as the sugar donor. This modification can alter protein function by regulating cellular signaling and transcription pathways in response to altered nutrient… read more here.
Keywords: inhibition; transferase ogt; glcnac transferase;
Deletion of Smooth Muscle O-GlcNAc Transferase Prevents Development of Atherosclerosis in Western Diet-Fed Hyperglycemic ApoE-/- Mice In Vivo
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24097899
Abstract: Accumulating evidence highlights protein O-GlcNAcylation as a putative pathogenic contributor of diabetic vascular complications. We previously reported that elevated protein O-GlcNAcylation correlates with increased atherosclerotic lesion formation and VSMC proliferation in response to hyperglycemia. However,… read more here.
Keywords: deletion; western diet; glcnac transferase; mice ... See more keywords