O‐GlcNAc Transferase: Structural Characteristics, Catalytic Mechanism and Small‐Molecule Inhibitors
Sign Up to like & getrecommendations! Published in 2020 at "ChemBioChem"
DOI: 10.1002/cbic.202000194
Abstract: Modifications of nuclear and cytoplasmic proteins with a single sugar, N‐acetylglucosamine (GlcNAc), play roles in a wide variety of fundamental cellular processes, and aberrant O‐GlcNAc profiles are associated with pathological progression of several chronic diseases.… read more here.
Keywords: glcnac transferase; catalytic mechanism; structural characteristics; transferase structural ... See more keywords
O‐GlcNAc transferase is required to maintain satellite cell function
Sign Up to like & getrecommendations! Published in 2021 at "STEM CELLS"
DOI: 10.1002/stem.3361
Abstract: O‐GlcNAcylation is a posttranslational modification considered to be a nutrient sensor that reports nutrient scarcity or surplus. Although O‐GlcNAcylation exists in a wide range of cells and/or tissues, its functional role in muscle satellite cells… read more here.
Keywords: glcnac transferase; muscle; glcnacylation; scs ... See more keywords
A lable-free SPR biosensor based on one peptide sequence with three recognition sites for O-GlcNAc transferase detection.
Sign Up to like & getrecommendations! Published in 2021 at "Talanta"
DOI: 10.1016/j.talanta.2020.121664
Abstract: Abnormal O-linked N-acetylglucosamine (O-GlcNAc) concentrations have been associated with many diseases, but the lack of accurate detection method limited O-GlcNAc to be used as a biomarker in clinical diagnosis. Then O-GlcNAc transferase (OGT) has drawn… read more here.
Keywords: ogt detection; glcnac transferase; peptide; spr biosensor ... See more keywords
Catalytic Promiscuity of O-GlcNAc Transferase Enables Unexpected Metabolic Engineering of Cytoplasmic Proteins with 2-Azido-2-deoxy-glucose.
Sign Up to like & getrecommendations! Published in 2017 at "ACS chemical biology"
DOI: 10.1021/acschembio.6b00876
Abstract: O-GlcNAc transferase (OGT) catalyzes the installation of N-acetylglucosamine (GlcNAc) O-linked to nucleocytoplasmic proteins (O-GlcNAc) within multicellular eukaryotes. OGT shows surprising tolerance for structural changes in the sugar component of its nucleotide sugar donor substrate, uridine… read more here.
Keywords: glcnac; azido deoxy; glcnac transferase; deoxy glucose ... See more keywords
Aspartate residues far from the active site drive O-GlcNAc transferase substrate selection.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.9b06061
Abstract: O-GlcNAc is an abundant post-translational modification found on nuclear and cytoplasmic proteins in all metazoans. This modification regulates a wide variety of cellular processes, and elevated O-GlcNAc levels have been implicated in cancer progression. A… read more here.
Keywords: glcnac; aspartate residues; substrate selection; glcnac transferase ... See more keywords
Electrophilic probes for deciphering substrate recognition by O-GlcNAc transferase
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DOI: 10.1038/nchembio.2494
Abstract: O-linked β-N-acetylglucosamine (O-GlcNAc) transferase (OGT) is an essential human glycosyltransferase that adds O-GlcNAc modifications on numerous proteins. However, little is known about how OGT recognizes various protein substrates. Here we report GlcNAc electrophilic probes (GEPs)… read more here.
Keywords: recognition; electrophilic probes; substrate recognition; glcnac transferase ... See more keywords
O-GlcNAc transferase regulates glioblastoma acetate metabolism via regulation of CDK5-dependent ACSS2 phosphorylation
Sign Up to like & getrecommendations! Published in 2022 at "Oncogene"
DOI: 10.1038/s41388-022-02237-6
Abstract: Glioblastomas (GBMs) preferentially generate acetyl-CoA from acetate as a fuel source to promote tumor growth. O-GlcNAcylation has been shown to be elevated by increasing O-GlcNAc transferase (OGT) in many cancers and reduced O-GlcNAcylation can block… read more here.
Keywords: glcnac transferase; acss2 ser; phosphorylation; growth ... See more keywords
Inhibition of O-GlcNAc transferase (OGT) by peptidic hybrids.
Sign Up to like & getrecommendations! Published in 2018 at "MedChemComm"
DOI: 10.1039/c8md00115d
Abstract: O-GlcNAc transferase (OGT) attaches a GlcNAc moiety on specific substrate proteins using UDP-GlcNAc as the sugar donor. This modification can alter protein function by regulating cellular signaling and transcription pathways in response to altered nutrient… read more here.
Keywords: inhibition; transferase ogt; glcnac transferase;
Deletion of Smooth Muscle O-GlcNAc Transferase Prevents Development of Atherosclerosis in Western Diet-Fed Hyperglycemic ApoE-/- Mice In Vivo
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24097899
Abstract: Accumulating evidence highlights protein O-GlcNAcylation as a putative pathogenic contributor of diabetic vascular complications. We previously reported that elevated protein O-GlcNAcylation correlates with increased atherosclerotic lesion formation and VSMC proliferation in response to hyperglycemia. However,… read more here.
Keywords: deletion; western diet; glcnac transferase; mice ... See more keywords