Bladder Cancer‐Derived Small Extracellular Vesicles Promote Tumor Angiogenesis by Inducing HBP‐Related Metabolic Reprogramming and SerRS O‐GlcNAcylation in Endothelial Cells
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Science"
DOI: 10.1002/advs.202202993
Abstract: A malformed tumour vascular network provokes the nutrient‐deprived tumour microenvironment (TME), which conversely activates endothelial cell (EC) functions and stimulates neovascularization. Emerging evidence suggests that the flexible metabolic adaptability of tumour cells helps to establish… read more here.
Keywords: extracellular vesicles; serrs glcnacylation; bladder cancer; small extracellular ... See more keywords
Chemical Biology Approaches to Understanding Neuronal O–GlcNAcylation
Sign Up to like & getrecommendations! Published in 2022 at "Israel journal of chemistry"
DOI: 10.1002/ijch.202200071
Abstract: O-linked β-N-acetylglucosamine (O–GlcNAc) is a ubiquitous post-translational modification in mammals, decorating thousands of intracellular proteins. O–GlcNAc cycling is an essential regulator of myriad aspects of cell physiology and is dysregulated in numerous human diseases. Notably,… read more here.
Keywords: neuronal glcnacylation; chemical biology; biology approaches; biology ... See more keywords
OGT upregulates myogenic IL-6 by mediating O-GlcNAcylation of p65 in mouse skeletal muscle under cold exposure.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of cellular physiology"
DOI: 10.1002/jcp.30612
Abstract: Cold exposure is an unavoidable and severe challenge for people and animals residing in cold regions of the world, and may lead to hypothermia, drastic changes in systemic metabolism, and inhibition of protein synthesis. O-linked-N-acetylglucoseaminylation… read more here.
Keywords: skeletal muscle; mouse skeletal; cold exposure; glcnacylation ... See more keywords
The role of O-GlcNAcylation mediated by OGT during tooth development.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of cellular physiology"
DOI: 10.1002/jcp.31024
Abstract: To understand the mechanisms underlying tooth morphogenesis, we examined the developmental roles of important posttranslational modification, O-GlcNAcylation, which regulates protein stability and activity by the addition and removal of a single sugar (O-GlcNAc) to the… read more here.
Keywords: morphogenesis; physiology; tooth development; stage ... See more keywords
O‐GlcNAc transferase is required to maintain satellite cell function
Sign Up to like & getrecommendations! Published in 2021 at "STEM CELLS"
DOI: 10.1002/stem.3361
Abstract: O‐GlcNAcylation is a posttranslational modification considered to be a nutrient sensor that reports nutrient scarcity or surplus. Although O‐GlcNAcylation exists in a wide range of cells and/or tissues, its functional role in muscle satellite cells… read more here.
Keywords: glcnac transferase; muscle; glcnacylation; scs ... See more keywords
O-GlcNAcylation in women’s cancers: breast, endometrial and ovarian
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Bioenergetics and Biomembranes"
DOI: 10.1007/s10863-017-9730-z
Abstract: O-GlcNAcylation is emerging as a critical regulatory post-translational modification, impacting proteins that regulate cell division, apoptosis, metabolism, cell signaling, and transcription. O-GlcNAc also affects biological homeostasis by integrating information coming from the environment, such as… read more here.
Keywords: glcnac; breast endometrial; glcnacylation; cancers breast ... See more keywords
O-GlcNAc in cancer: An Oncometabolism-fueled vicious cycle
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Bioenergetics and Biomembranes"
DOI: 10.1007/s10863-018-9751-2
Abstract: Cancer cells exhibit unregulated growth, altered metabolism, enhanced metastatic potential and altered cell surface glycans. Fueled by oncometabolism and elevated uptake of glucose and glutamine, the hexosamine biosynthetic pathway (HBP) sustains glycosylation in the endomembrane… read more here.
Keywords: glcnac; oncometabolism; glcnacylation; cycle ... See more keywords
FOXA2 inhibits doxorubicin-induced apoptosis via transcriptionally activating HBP rate-limiting enzyme GFPT1 in HCC cells.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of physiology and biochemistry"
DOI: 10.1007/s13105-021-00829-6
Abstract: Apoptosis plays an important role in both carcinogenesis and cancer treatment. Understanding the mechanisms through which resistance to apoptosis occurs in cancer cells has huge implications for cancer treatment. Although pieces of evidence have shown… read more here.
Keywords: foxa2; apoptosis; induced apoptosis; hcc cells ... See more keywords
Bittersweet tumor development and progression: Emerging roles of epithelial plasticity glycosylations
Sign Up to like & getrecommendations! Published in 2019 at "Advances in Cancer Research"
DOI: 10.1016/bs.acr.2019.01.002
Abstract: &NA; Altered metabolism is one of the hallmarks of cancer. The best‐known cancer metabolic anomaly is an increase in aerobic glycolysis, which generates ATP and other basic building blocks, such as nucleotides, lipids, and proteins… read more here.
Keywords: glcnacylation; cancer; development; epithelial plasticity ... See more keywords
Parallel study on protein O-GlcNAcylation in prostate cancer cell with a sensitive microarray biochip.
Sign Up to like & getrecommendations! Published in 2018 at "Analytical biochemistry"
DOI: 10.1016/j.ab.2018.08.004
Abstract: Although a variety of approaches have been developed to analyze protein O-GlcNAcylation, efficient investigations on O-GlcNAcylation of proteins of interest in high-throughput manner are still in high demand to further explore its functionality. In this… read more here.
Keywords: prostate cancer; glcnacylation; protein glcnacylation; cancer cell ... See more keywords
Elevated O-GlcNAcylation stabilizes FOXM1 by its reduced degradation through GSK-3β inactivation in a human gastric carcinoma cell line, MKN45 cells.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.11.179
Abstract: O-GlcNAcylation is a dynamic post-translational modification of cytonuclear proteins for intracellular signaling. Elevated O-GlcNAcylation is a general feature of cancer and contributes to cancer progression, and recent studies indicate the contribution to increasing incidence of… read more here.
Keywords: mkn45 cells; foxm1 protein; degradation; glcnacylation ... See more keywords