O-GlcNAcylation of SIRT1 enhances its deacetylase activity and promotes cytoprotection under stress
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DOI: 10.1038/s41467-017-01654-6
Abstract: SIRT1 is the most evolutionarily conserved mammalian sirtuin, and it plays a vital role in the regulation of metabolism, stress responses, genome stability, and ageing. As a stress sensor, SIRT1 deacetylase activity is significantly increased… read more here.
Keywords: deacetylase activity; stress; glcnacylation sirt1;