Consequences of excessive glucosylsphingosine in glucocerebrosidase-deficient zebrafish.
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DOI: 10.1016/j.jlr.2022.100199
Abstract: In Gaucher disease (GD), the deficiency of glucocerebrosidase (GCase/ GBA1) causes lysosomal accumulation of glucosylceramide (GlcCer), which is partly converted by acid ceramidase (ACase) to glucosylsphingosine (GlcSph) in the lysosome. Chronically elevated blood and tissue… read more here.
Keywords: glcsph; deficient zebrafish; glucocerebrosidase deficient; excessive glcsph ... See more keywords