Downregulation of glycine decarboxylase enhanced cofilin‐mediated migration in hepatocellular carcinoma cells
Sign Up to like & getrecommendations! Published in 2018 at "Free Radical Biology and Medicine"
DOI: 10.1016/j.freeradbiomed.2018.03.003
Abstract: ABSTRACT Metabolic reprogramming is a hallmark of cancer. Glycine decarboxylase (GLDC), an oxidoreductase, plays an important role in amino acid metabolism. While GLDC promotes tumor initiation and proliferation in non‐small cell lung cancer and glioma… read more here.
Keywords: gldc; hcc; migration; cofilin ... See more keywords
Glycine decarboxylase is a transcriptional target of MYCN required for neuroblastoma cell proliferation and tumorigenicity
Sign Up to like & getrecommendations! Published in 2019 at "Oncogene"
DOI: 10.1038/s41388-019-0967-3
Abstract: Genomic amplification of the oncogene MYCN is a major driver in the development of high-risk neuroblastoma, a pediatric cancer with poor prognosis. Given the challenge in targeting MYCN directly for therapy, we sought to identify… read more here.
Keywords: gldc; transcriptional target; mycn; proliferation ... See more keywords
Downregulation of Gldc attenuates myocardial ischemia reperfusion injury in vitro by modulating Akt and NF-κB signalings
Sign Up to like & getrecommendations! Published in 2025 at "Scientific Reports"
DOI: 10.1038/s41598-024-79445-5
Abstract: Myocardial ischemia/reperfusion injury (MIRI) is a serious clinical complication that is caused by reperfusion therapy following myocardial infarction (MI). Mitochondria-related genes (Mito-RGs) play important roles in multiple diseases. However, the role of mitochondria-related genes in… read more here.
Keywords: myocardial ischemia; ischemia reperfusion; reperfusion; gldc ... See more keywords
Glycine decarboxylase advances IgA nephropathy by boosting mesangial cell proliferation through the pyrimidine pathway
Sign Up to like & getrecommendations! Published in 2025 at "EMBO Molecular Medicine"
DOI: 10.1038/s44321-025-00315-2
Abstract: The proliferation of glomerular mesangial cells is a fundamental pathological change in immunoglobulin A nephropathy (IgAN). This study aims to elucidate the mechanisms that affect the proliferation of glomerular mesangial cells. Bioinformatics analysis combined with… read more here.
Keywords: cell proliferation; gldc; proliferation; mesangial cell ... See more keywords
Highlights from the literature
Sign Up to like & getrecommendations! Published in 2022 at "Archives of Disease in Childhood"
DOI: 10.1136/archdischild-2022-324260
Abstract: To sustain rapid tumor growth, glioma cells must have the ability to adapt in order to survive in their rapidly changing and often harsh microenvironment. A recent study in the journal Nature elegantly describes a… read more here.
Keywords: glioblastoma cells; shmt2; glycine; glioma cells ... See more keywords
Glycine decarboxylase deficiency-induced motor dysfunction in zebrafish is rescued by counterbalancing glycine synaptic level.
Sign Up to like & getrecommendations! Published in 2018 at "JCI insight"
DOI: 10.1172/jci.insight.124642
Abstract: Glycine encephalopathy (GE), or nonketotic hyperglycinemia (NKH), is a rare recessive genetic disease caused by defective glycine cleavage and characterized by increased accumulation of glycine in all tissues. Here, based on new case reports of… read more here.
Keywords: gldc; level; motor; glycine ... See more keywords
gldc Is Essential for Renal Progenitor Patterning during Kidney Development
Sign Up to like & getrecommendations! Published in 2022 at "Biomedicines"
DOI: 10.3390/biomedicines10123220
Abstract: The glycine cleavage system (GCS) is a complex located on the mitochondrial membrane that is responsible for regulating glycine levels and contributing one-carbon units to folate metabolism. Congenital mutations in GCS components, such as glycine… read more here.
Keywords: kidney; development; glycine; renal progenitor ... See more keywords