Unfavorable Intermediate‐Risk Prostate Cancer and the Odds of Upgrading to Gleason 8 or Higher at Prostatectomy
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DOI: 10.1016/j.clgc.2016.06.001
Abstract: Micro‐Abstract In order to decide whether to administer radiation and a short or long course of androgen deprivation therapy in men with unfavorable intermediate‐risk prostate cancer, multiparametric magnetic resonance imaging could be considered when the… read more here.
Keywords: gleason; score higher; intermediate risk; unfavorable intermediate ... See more keywords
Validation of a Contemporary Five-tiered Gleason Grade Grouping Using Population-based Data.
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DOI: 10.1016/j.eururo.2016.11.031
Abstract: This population-based study assesses whether a proposed five-tiered Gleason grade grouping (GGG) system predicts prostate cancer-specific mortality (PCSM). Using the Surveillance, Epidemiology, and End Results (SEER) database, we identified 331320 prostate cancer patients who had… read more here.
Keywords: five tiered; gleason; system; population based ... See more keywords
Gleason score 5+3=8 (grade group 4) prostate cancer - a rare occurrence with contemporary grading.
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DOI: 10.1016/j.humpath.2019.11.002
Abstract: Grade Group (GG) 4 prostate cancer includes Gleason scores (GS) 3+5=8, 4+4=8, and 5+3=8. Some studies without pathology re-review of historical cohorts proposed that the presence of pattern 5 worsens prognosis compared to GS 4+4=8… read more here.
Keywords: gleason; grade group; grade; pathology ... See more keywords
Accurate pattern-based extraction of complex Gleason score expressions from pathology reports
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DOI: 10.1016/j.jbi.2021.103850
Abstract: PURPOSE The Gleason score is an important grading factor of prostate cancer. Gleason scores can be extracted from pathology report texts using regular expressions, but previously developed programmes have targeted only relatively simple Gleason score… read more here.
Keywords: gleason; pathology; gleason score; complex gleason ... See more keywords
The prognostic role of tertiary Gleason pattern 5 in a contemporary grading system for prostate cancer
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DOI: 10.1038/pcan.2016.55
Abstract: BACKGROUND:Recently, a new prostate cancer (PC) grading system has been introduced, where Gleason score (GS) 7 (3+4) and GS 7 (4+3) are categorized into two separate groups. However, GS 7 with tertiary Gleason pattern 5… read more here.
Keywords: bcr; gleason; prostate cancer; grading system ... See more keywords
Seminal metabolomics distinguish Gleason grades
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DOI: 10.1038/s41585-021-00495-9
Abstract: Metabolomic profiling of seminal fluid might enable differentiation of indolent prostate cancer from aggressive disease, according to a recent study. Semen samples collected from otherwise healthy individuals (n = 13) before infertility treatment and patients… read more here.
Keywords: gleason; seminal metabolomics; prostate cancer; metabolomics distinguish ... See more keywords
A critical evaluation of visual proportion of Gleason 4 and maximum cancer core length quantified by histopathologists
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DOI: 10.1038/s41598-020-73524-z
Abstract: Gleason score 7 prostate cancer with a higher proportion of pattern 4 (G4) has been linked to genomic heterogeneity and poorer patient outcome. The current assessment of G4 proportion uses estimation by a pathologist, with… read more here.
Keywords: cancer core; gleason; estimation; maximum cancer ... See more keywords
Deep Learning-Based Gleason Grading of Prostate Cancer From Histopathology Images—Role of Multiscale Decision Aggregation and Data Augmentation
Sign Up to like & getrecommendations! Published in 2020 at "IEEE Journal of Biomedical and Health Informatics"
DOI: 10.1109/jbhi.2019.2944643
Abstract: Visual inspection of histopathology images of stained biopsy tissue by expert pathologists is the standard method for grading of prostate cancer (PCa). However, this process is time-consuming and subject to high inter-observer variability. Machine learning-based… read more here.
Keywords: learning based; augmentation; histopathology; data augmentation ... See more keywords
Primary Gleason grade and Gleason grade group at positive surgical margins: a systematic review and meta‐analysis
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DOI: 10.1111/bju.15316
Abstract: To systematically review and perform a meta‐analysis of studies investigating the role of primary Gleason grade (PGG), Gleason score (GS) or Gleason grade group (GGG) at positive surgical margins (PSMs) after radical prostatectomy (RP) in… read more here.
Keywords: gleason; primary gleason; positive surgical; grade group ... See more keywords
Impact of Gleason pattern 5 on prognosis for newly diagnosed metastatic hormone‐sensitive prostate cancer with Gleason score ≥8
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DOI: 10.1111/iju.14781
Abstract: We evaluated the impact of Gleason pattern 5 presence on prognosis among de novo metastatic hormone‐sensitive prostate cancer patients with a Gleason score ≥8. read more here.
Keywords: impact gleason; metastatic hormone; hormone sensitive; gleason pattern ... See more keywords
Pathology-Driven Comprehensive Proteomic Profiling of the Prostate Cancer Tumor Microenvironment
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DOI: 10.1158/1541-7786.mcr-16-0358
Abstract: Prostate cancer is the second most common cancer in men worldwide. Gleason grading is an important predictor of prostate cancer outcomes and is influential in determining patient treatment options. Clinical decisions based on a Gleason… read more here.
Keywords: gleason; prostate cancer; pathology; cancer ... See more keywords