Targeting class I histone deacetylases by the novel small molecule inhibitor 4SC‐202 blocks oncogenic hedgehog‐GLI signaling and overcomes smoothened inhibitor resistance
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Cancer"
DOI: 10.1002/ijc.31117
Abstract: Aberrant activation of Hedgehog (HH)/GLI signaling is causally involved in numerous human malignancies, including basal cell carcinoma (BCC) and medulloblastoma. HH pathway antagonists targeting smoothened (SMO), an essential effector of canonical HH/GLI signaling, show significant… read more here.
Keywords: inhibitor; 4sc 202; treatment; resistance ... See more keywords
Unveiling anticancer potential of glibenclamide: Its synergistic cytotoxicity with doxorubicin on cancer cells
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Pharmaceutical and Biomedical Analysis"
DOI: 10.1016/j.jpba.2018.03.025
Abstract: HIGHLIGHTSGlibenclamide interacts with DNA through groove binding.The spectrometric and electrochemical studies reveal direct interaction of Glibenclamide with DNA.The interaction between Glibenclamide and B‐form of DNA is thermodynamically favorable.Glibenclamide synergistically enhances the cytotoxicity of Doxorubicin against… read more here.
Keywords: glibenclamide; dna; spectroscopy; interaction ... See more keywords
Indolactam Dipeptides as Nanomolar Gli Inhibitors.
Sign Up to like & getrecommendations! Published in 2022 at "ACS medicinal chemistry letters"
DOI: 10.1021/acsmedchemlett.1c00562
Abstract: The Gli transcription factors within the Hedgehog (Hh) signaling pathway play essential roles in human development. However, the reactivation of Gli proteins in adult tissue is tumorigenic and drives the progression of several cancers, including… read more here.
Keywords: dipeptides nanomolar; chemistry; indolactam dipeptides; gli inhibitors ... See more keywords
The Shh/Gli signaling cascade regulates myofibroblastic activation of lung-resident mesenchymal stem cells via the modulation of Wnt10a expression during pulmonary fibrogenesis
Sign Up to like & getrecommendations! Published in 2019 at "Laboratory Investigation"
DOI: 10.1038/s41374-019-0316-8
Abstract: Lung-resident mesenchymal stem cells (LR-MSCs) are important regulators of lung repair and regeneration, and evidence suggests that this cell population also plays a vital role in fibrosis. Crosstalk between sonic hedgehog (Shh) signaling and wingless/integrated… read more here.
Keywords: signaling cascade; shh; pulmonary fibrosis; gli ... See more keywords
Foxm1 controls a pro-stemness microRNA network in neural stem cells
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-21876-y
Abstract: Cerebellar neural stem cells (NSCs) require Hedgehog-Gli (Hh-Gli) signalling for their maintenance and Nanog expression for their self-renewal. To identify novel molecular features of this regulatory pathway, we used next-generation sequencing technology to profile mRNA… read more here.
Keywords: microrna network; stem cells; neural stem; gli ... See more keywords
Changes in interpretation of spirometry by implementing the GLI 2012 reference equations: impact on patients tested in a hospital-based PFT lab in a large metropolitan city
Sign Up to like & getrecommendations! Published in 2022 at "BMJ Open Respiratory Research"
DOI: 10.1136/bmjresp-2022-001389
Abstract: Background The Global Lung Function Initiative (GLI-2012) focused on race/ethnicity as an important factor in determining reference values. This study evaluated the effects of changing from Canadian reference equations developed from an all-Caucasian cohort with… read more here.
Keywords: gli race; reference; reference equations; gli ... See more keywords
Assessment of Global Lung Function Initiative (GLI) reference equations for diffusing capacity in relation to respiratory burden in the Swedish CArdioPulmonary bioImage Study (SCAPIS)
Sign Up to like & getrecommendations! Published in 2020 at "European Respiratory Journal"
DOI: 10.1183/13993003.01995-2019
Abstract: The Global Lung Function Initiative (GLI) has recently published international reference values for diffusing capacity of the lung for carbon monoxide (DLCO). Lower limit of normal (LLN), i.e. the 5th percentile, usually defines impaired DLCO.… read more here.
Keywords: lln; dlco gli; gli; scapis lln ... See more keywords
Regulation of capillary hemodynamics by KATP channels in resting skeletal muscle
Sign Up to like & getrecommendations! Published in 2021 at "Physiological Reports"
DOI: 10.14814/phy2.14803
Abstract: ATP‐sensitive K+ channels (KATP) have been implicated in the regulation of resting vascular smooth muscle membrane potential and tone. However, whether KATP channels modulate skeletal muscle microvascular hemodynamics at the capillary level (the primary site… read more here.
Keywords: skeletal muscle; muscle; katp channels; resting skeletal ... See more keywords
Combined targeting of HEDGEHOG signaling and BRD4 as a novel therapeutic option against melanoma
Sign Up to like & getrecommendations! Published in 2023 at "Oncotarget"
DOI: 10.18632/oncotarget.28441
Abstract: The Hedgehog-GLI (HH/GLI) pathway is aberrantly activated in several types of cancer. Canonical HH/ GLI pathway is triggered by binding of HH ligands to the twelve-pass transmembrane receptor Patched 1 (PTCH1), which retrieves its inhibition… read more here.
Keywords: hedgehog signaling; hedgehog; targeting hedgehog; gli ... See more keywords
Mediators of human ureteral smooth muscle contraction-a role for erythropoietin, tamsulosin and Gli effectors.
Sign Up to like & getrecommendations! Published in 2021 at "Translational andrology and urology"
DOI: 10.21037/tau-20-1342
Abstract: Background Ureteral contractility is a poorly understood process. Contractions have been demonstrated to occur in the smooth muscle layers of the ureter. Previous work suggests the involvement of Gli family proteins and erythropoietin (EPO) in… read more here.
Keywords: ureteral smooth; human ureteral; muscle; smooth muscle ... See more keywords
SYNTHESIS AND ANALYSIS OF ZINC METHIONINE, ZINC GLYCINE, COPPER LEUCINE, AND COPPER GLYCINE COMPLEXES USING ATOMIC ABSORPTION SPECTROPHOTOMETRY
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Applied Pharmaceutics"
DOI: 10.22159/ijap.2018.v10s1.86
Abstract: Objective: The aim of this study was to perform metal-amino acid synthesis and to analyze the free and bonded mineral concentrations.Methods: In this study, the synthesis of amino acid metal complexes was carried out by… read more here.
Keywords: zinc; zinc methionine; copper; glycine ... See more keywords