Timing is everything: Transcriptional repression is not the default mode for regulating Hedgehog signaling
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DOI: 10.1002/bies.202200139
Abstract: Hedgehog (HH) signaling is a conserved pathway that drives developmental growth and is essential for the formation of most organs. The expression of HH target genes is regulated by a dual switch mechanism where GLI… read more here.
Keywords: hedgehog signaling; default; hedgehog; gli proteins ... See more keywords
Multiprotein GLI Transcriptional Complexes as Therapeutic Targets in Cancer
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DOI: 10.3390/life12121967
Abstract: The Hedgehog signaling pathway functions in both embryonic development and adult tissue homeostasis. Importantly, its aberrant activation is also implicated in the progression of multiple types of cancer, including basal cell carcinoma and medulloblastoma. GLI… read more here.
Keywords: transcriptional activity; gli proteins; gli transcriptional; multiprotein gli ... See more keywords