Functional Disruption of Gli1‐DNA Recognition via a Cobalt(III) Complex
Sign Up to like & getrecommendations! Published in 2022 at "ChemMedChem"
DOI: 10.1002/cmdc.202200025
Abstract: The aberrant activation of the Gli family of zinc finger transcription factors (ZFTFs) is associated with several types of human cancer, including medulloblastoma and basal cell carcinoma. We have reported the use of cobalt(III) Schiff‐base… read more here.
Keywords: dna; cobalt iii; gli1; dna recognition ... See more keywords
Expanding the spectrum of GLI1‐altered mesenchymal tumors—A high‐grade uterine sarcoma harboring a novel PAMR1::GLI1 fusion and literature review of GLI1‐altered mesenchymal neoplasms of the gynecologic tract
Sign Up to like & getrecommendations! Published in 2022 at "Genes"
DOI: 10.1002/gcc.23099
Abstract: GLI1‐altered mesenchymal tumors comprise a group of seemingly unrelated entities, including pericytoma with t(7;12) translocation, plexiform fibromyxoma, gastroblastoma, malignant epithelioid neoplasm with GLI1 rearrangements, and GLI1‐amplified mesenchymal neoplasms. Herein, we report a high‐grade uterine sarcoma… read more here.
Keywords: fusion; mesenchymal neoplasms; sarcoma; gli1 altered ... See more keywords
Differential role of Pax6 and its interaction with Shh–Gli1–IDH2 axis in regulation of glioma growth and chemoresistance
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.23241
Abstract: Glioma is a major brain tumor, and the associated mortality rate is very high. Contemporary therapies provide a chance of survival for 9–12 months. Therefore, a novel approach is essential to improve the survival rate.… read more here.
Keywords: shh gli1; gli1; gli1 idh2; pax6 ... See more keywords
Expression of tumour transcription factor GLI1 in canine mammary tumours tissue
Sign Up to like & getrecommendations! Published in 2022 at "Veterinary Medicine and Science"
DOI: 10.1002/vms3.830
Abstract: Abstract Background Mammary tumor is one of the most common diseases of canine in pet clinics. Objectives This study investigates the distribution and expression of the tumor transcription factor GLI1 and the downstream proteins, Bmi1… read more here.
Keywords: gli1; expression; canine mammary; bmi1 ... See more keywords
Immunohistochemical evaluation of Sonic Hedgehog signaling pathway proteins (Shh, Ptch1, Ptch2, Smo, Gli1, Gli2, and Gli3) in sporadic and syndromic odontogenic keratocysts
Sign Up to like & getrecommendations! Published in 2018 at "Clinical Oral Investigations"
DOI: 10.1007/s00784-018-2421-2
Abstract: AimsThe aim of this study was to compare the clinical and demographic features of 62 patients presenting sporadic odontogenic keratocysts (OKCs) or OKCs associated with nevoid basal cell carcinoma syndrome (NBCCS). In conjunction with this,… read more here.
Keywords: shh ptch1; smo; ptch1 ptch2; gli1 ... See more keywords
Identification of a DYRK1A-mediated phosphorylation site within the nuclear localization sequence of the hedgehog transcription factor GLI1.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.07.107
Abstract: GLI1 is a key downstream transcription effector of the Hedgehog (Hh) signaling pathway that is involved in promoting cell growth, differentiation and tissue patterning in embryonic development. GLI1 over-activation and its nuclear localization has also… read more here.
Keywords: localization sequence; nuclear localization; gli1; site ... See more keywords
A Role for the Hedgehog Effector Gli1 in Mediating Stent-induced Ureteral Smooth Muscle Dysfunction and Aperistalsis.
Sign Up to like & getrecommendations! Published in 2017 at "Urology"
DOI: 10.1016/j.urology.2017.01.029
Abstract: OBJECTIVE To better understand the effects of double J stenting on ureteral physiology and function. MATERIALS AND METHODS In total, 24 pigs were stented cystoscopically unilaterally for 48 hours, 1, 2, 4, and 7 weeks.… read more here.
Keywords: ureteral smooth; gli1; hedgehog; expression ... See more keywords
Circ_DCAF6 potentiates cell stemness and growth in breast cancer through GLI1-Hedgehog pathway.
Sign Up to like & getrecommendations! Published in 2020 at "Experimental and molecular pathology"
DOI: 10.1016/j.yexmp.2020.104492
Abstract: Circular RNAs (circRNAs) are extensively revealed as a malignant activator or suppressor in multiple pathological processes including cancer cell stemness and growth. However, the association of circ_DCAF6 with breast cancer (BC) cell growth and stemness… read more here.
Keywords: circ dcaf6; gli1; dcaf6; cancer ... See more keywords
Quinolines and Oxazino-quinoline Derivatives as Small Molecule GLI1 Inhibitors Identified by Virtual Screening.
Sign Up to like & getrecommendations! Published in 2022 at "ACS medicinal chemistry letters"
DOI: 10.1021/acsmedchemlett.2c00249
Abstract: A virtual screening approach based on a five-feature pharmacophoric model for negative modulators of GLI1 was applied to databases of commercially available compounds. The resulting quinoline derivatives showed significant ability to reduce the GLI1 protein… read more here.
Keywords: quinoline derivatives; quinolines oxazino; derivatives small; virtual screening ... See more keywords
Tumour suppressor 15-hydroxyprostaglandin dehydrogenase induces differentiation in colon cancer via GLI1 inhibition
Sign Up to like & getrecommendations! Published in 2020 at "Oncogenesis"
DOI: 10.1038/s41389-020-00256-0
Abstract: Inflammation is an established risk factor for colorectal cancer. We and others have shown that colorectal cancer patients with elevated cysteinyl leukotriene receptor 2 (CysLT2R) and 15-hydroxyprostaglandin dehydrogenase (15-PGDH) levels exhibit good prognoses. However, both… read more here.
Keywords: gli1; pgdh; colorectal cancer; colon cancer ... See more keywords
The regulation of Hh/Gli1 signaling cascade involves Gsk3β- mediated mechanism in estrogen-derived endometrial hyperplasia
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-06370-1
Abstract: The present study was undertaken to explore the functional involvement of Hh signaling and its regulatory mechanism in endometrial hyperplasia. Differential expression of Hh signaling molecules i.e., Ihh, Shh, Gli1 or Gsk3β was observed in… read more here.
Keywords: mechanism; gli1; estrogen; expression ... See more keywords