Targeting the hedgehog transcription factors GLI1 and GLI2 restores sensitivity to vemurafenib-resistant human melanoma cells
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DOI: 10.1038/onc.2016.348
Abstract: BRAF inhibitor (BRAFi) therapy for melanoma patients harboring the V600E mutation is initially highly effective, but almost all patients relapse within a few months. Understanding the molecular mechanisms underpinning BRAFi-based therapy is therefore an important… read more here.
Keywords: melanoma; gli1 gli2; brafi; vemurafenib resistant ... See more keywords
Unique and overlapping GLI1 and GLI2 transcriptional targets in neoplastic chondrocytes
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DOI: 10.1371/journal.pone.0211333
Abstract: Excessive Hedgehog (Hh) signaling in chondrocytes is sufficient to cause formation of enchondroma-like lesions which can progress to chondrosarcoma. To elucidate potential underlying mechanisms, we identified GLI1 and GLI2 target genes in human chondrosarcoma. Using… read more here.
Keywords: gli1 gli2; neoplastic chondrocytes; unique overlapping; gli2 transcriptional ... See more keywords
The Role of GLI in the Regulation of Hepatic Epithelial–Mesenchymal Transition in Biliary Atresia
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DOI: 10.3389/fped.2022.861826
Abstract: Objective To study the regulatory role of GLI1/GLI2, a nuclear transcription factor of the Sonic hedgehog (Shh) signaling pathway, in epithelial–mesenchymal transition (EMT) related to hepatic fibrosis in patients with biliary atresia (BA). Methods The… read more here.
Keywords: mesenchymal transition; role; biliary atresia; expression ... See more keywords