Tooth agenesis-related GLI2 and GLI3 genes may contribute to craniofacial skeletal morphology in humans.
Sign Up to like & getrecommendations! Published in 2019 at "Archives of oral biology"
DOI: 10.1016/j.archoralbio.2019.05.008
Abstract: OBJECTIVE The present cross-sectional, multi-centre, genetic study aimed to determine, whether single nucleotide polymorphisms (SNPs) in tooth agenesis (TA)-associated GLI2 and GLI3 genes contribute to the development of craniofacial skeletal morphology in humans. DESIGN Orthodontic… read more here.
Keywords: tooth agenesis; gli3 genes; gli2 gli3; gli3 ... See more keywords
Transcriptional repression of the tyrosinase-related protein 2 gene by transforming growth factor-β and the Kruppel-like transcription factor GLI2.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of dermatological science"
DOI: 10.1016/j.jdermsci.2019.04.001
Abstract: BACKGROUND Tyrosinase-Related Protein 2 (TRP2) is an enzyme involved in melanogenesis, that also exerts proliferative, anti-apoptotic and immunogenic functions in melanoma cells. TRP2 transcription is regulated by the melanocytic master transcription factor MITF. GLI2, a… read more here.
Keywords: gli2; factor; repression; transcription factor ... See more keywords
Gli2 is required for the induction and migration of Xenopus laevis neural crest
Sign Up to like & getrecommendations! Published in 2018 at "Mechanisms of Development"
DOI: 10.1016/j.mod.2018.07.010
Abstract: The neural crest (NC) is a multipotent migratory embryonic population that is formed during late gastrulation and gives rise to a wide array of derivatives, including cells from the peripheral nervous system (PNS), the craniofacial… read more here.
Keywords: xenopus; gli2 required; neural crest; required induction ... See more keywords
The transcript ENST00000444125 of lncRNA LINC01503 promotes cancer stem cell properties of glioblastoma cells via reducing FBXW1 mediated GLI2 degradation.
Sign Up to like & getrecommendations! Published in 2022 at "Experimental cell research"
DOI: 10.1016/j.yexcr.2022.113009
Abstract: LINC010503 is a novel oncogenic lncRNA in multiple cancers. In this study, we further explored the expression of LINC010503 transcripts and their regulations on the glioblastoma (GBM) stem cell (GSC) properties. LINC01503 transcription patterns in… read more here.
Keywords: gli2; cells via; transcript; cell ... See more keywords
Novel GLI2 mutations identified in patients with Combined Pituitary Hormone Deficiency (CPHD): Evidence for a pathogenic effect by functional characterization
Sign Up to like & getrecommendations! Published in 2019 at "Clinical Endocrinology"
DOI: 10.1111/cen.13914
Abstract: The Gli‐family of zinc‐finger transcription factors regulates the Sonic Hedgehog (Shh) signalling pathway that plays a key role in early pituitary and ventral forebrain development. Heterozygous GLI2 loss of function mutations in humans have been… read more here.
Keywords: combined pituitary; hormone deficiency; pituitary hormone; gli2 ... See more keywords
Suppressive GLI2 fragment enhances liver metastasis in colorectal cancer
Sign Up to like & getrecommendations! Published in 2022 at "Oncotarget"
DOI: 10.18632/oncotarget.28170
Abstract: Linoleic acid (LA) has been shown to cause inflammation and promote development of colorectal cancer (CRC). Moreover, many literatures show that LA is associated with cancer metastasis. Metastatic cancer cells have high stemness, suggesting that… read more here.
Keywords: cancer cells; suppressive gli2; colorectal cancer; liver metastasis ... See more keywords
The GLI2 Missense Variant rs3738880 Significantly Increases the Risk of Neural Tube Defects in the Han Chinese Population
Sign Up to like & getrecommendations! Published in 2017 at "Reproductive and Developmental Medicine"
DOI: 10.4103/2096-2924.224214
Abstract: Background: The sonic hedgehog (SHH) pathway is an important signaling pathway for neural tube closure. GLI family zinc finger 2 (GLI2) is the major activation mediator of the SHH pathway; however, no single-nucleotide polymorphisms (SNPs)… read more here.
Keywords: neural tube; rs3738880 significantly; han chinese; chinese population ... See more keywords
Hedgehog signaling via Gli2 prevents obesity induced by high-fat diet in adult mice
Sign Up to like & getrecommendations! Published in 2017 at "eLife"
DOI: 10.7554/elife.31649
Abstract: Obesity poses a significant risk of developing type II diabetes and other diseases. Hedgehog (Hh) signaling has been shown to inhibit adipose tissue development, but its effect on diet-induced obesity during postnatal life is not… read more here.
Keywords: fat diet; hedgehog signaling; high fat; mice ... See more keywords