Tooth agenesis-related GLI2 and GLI3 genes may contribute to craniofacial skeletal morphology in humans.
Sign Up to like & getrecommendations! Published in 2019 at "Archives of oral biology"
DOI: 10.1016/j.archoralbio.2019.05.008
Abstract: OBJECTIVE The present cross-sectional, multi-centre, genetic study aimed to determine, whether single nucleotide polymorphisms (SNPs) in tooth agenesis (TA)-associated GLI2 and GLI3 genes contribute to the development of craniofacial skeletal morphology in humans. DESIGN Orthodontic… read more here.
Keywords: tooth agenesis; gli3 genes; gli2 gli3; gli3 ... See more keywords
PO-186 Generation of the GLI1, GLI2 and GLI3 knock-out ovarian cancer cell lines using the CRISPR/Cas9
Sign Up to like & getrecommendations! Published in 2018 at "ESMO Open"
DOI: 10.1136/esmoopen-2018-eacr25.707
Abstract: Introduction Hedgehog signalling pathway is a developmental signalling pathway which is dormant in most adult differentiated tissues, but aberrantly activated in various tumours. In ovarian tumours it can be activated in a canonical way, by… read more here.
Keywords: knock; cell; ovarian cancer; gli2 gli3 ... See more keywords
Combinatorial Gli activity directs immune infiltration and tumor growth in pancreatic cancer
Sign Up to like & getrecommendations! Published in 2022 at "PLoS Genetics"
DOI: 10.1371/journal.pgen.1010315
Abstract: Proper Hedgehog (HH) signaling is essential for embryonic development, while aberrant HH signaling drives pediatric and adult cancers. HH signaling is frequently dysregulated in pancreatic cancer, yet its role remains controversial, with both tumor-promoting and… read more here.
Keywords: pancreatic cancer; immune infiltration; gli2 gli3; tumor ... See more keywords