Two nonsense GLI3 variants are associated with polydactyly and syndactyly in two families by affecting the sonic hedgehog signaling pathway.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular genetics & genomic medicine"
DOI: 10.1002/mgg3.1895
Abstract: BACKGROUND Polydactyly and syndactyly are congenital limb deformities, segregating in an autosomal-dominant fashion. The variants in the GLI3 gene are closely related to congenital limb malformations. However, the causes underlying polydactyly and syndactyly are not… read more here.
Keywords: gli3; two families; polydactyly syndactyly; gli3 variant ... See more keywords
Tooth agenesis-related GLI2 and GLI3 genes may contribute to craniofacial skeletal morphology in humans.
Sign Up to like & getrecommendations! Published in 2019 at "Archives of oral biology"
DOI: 10.1016/j.archoralbio.2019.05.008
Abstract: OBJECTIVE The present cross-sectional, multi-centre, genetic study aimed to determine, whether single nucleotide polymorphisms (SNPs) in tooth agenesis (TA)-associated GLI2 and GLI3 genes contribute to the development of craniofacial skeletal morphology in humans. DESIGN Orthodontic… read more here.
Keywords: tooth agenesis; gli3 genes; gli2 gli3; gli3 ... See more keywords
miR-7-5p acts as a tumor suppressor in bladder cancer by regulating the hedgehog pathway factor Gli3.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2018.07.166
Abstract: Although important progresses have been made in the diagnosis and treatment of bladder cancer (BCa), the overall survival for patients with advanced BCa remains poor. It is necessary to uncover the molecular mechanism underlying the… read more here.
Keywords: bladder cancer; gli3; bca; hedgehog pathway ... See more keywords
Zic5 stabilizes Gli3 via a non-transcriptional mechanism during retinal development.
Sign Up to like & getrecommendations! Published in 2022 at "Cell reports"
DOI: 10.1016/j.celrep.2022.110312
Abstract: The Zic family of zinc finger transcription factors plays a critical role in multiple developmental processes. Using loss-of-function studies, we find that Zic5 is important for the differentiation of retinal pigmented epithelium (RPE) and the… read more here.
Keywords: development; zic5 stabilizes; gli3; gli3 via ... See more keywords
Cadherin-7 enhances Sonic Hedgehog signalling by preventing Gli3 repressor formation during neural tube patterning
Sign Up to like & getrecommendations! Published in 2017 at "Open Biology"
DOI: 10.1098/rsob.170225
Abstract: Sonic Hedgehog (Shh) is a ventrally enriched morphogen controlling dorsoventral patterning of the neural tube. In the dorsal spinal cord, Gli3 protein bound to suppressor-of-fused (Sufu) is converted into Gli3 repressor (Gli3R), which inhibits Shh-target… read more here.
Keywords: gli3 repressor; gli3; formation; neural tube ... See more keywords
Coexpression of EphA10 and Gli3 promotes breast cancer cell proliferation, invasion and migration
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Investigative Medicine"
DOI: 10.1136/jim-2021-001836
Abstract: This study investigated the influences of EphA10 and Gli3 on breast cancer (BC) cell proliferation, invasion and migration. Immunohistochemistry was used to reveal the expressions of EphA10 and Gli3 in 18 intraductal carcinomas, 124 invasive… read more here.
Keywords: invasion migration; epha10 gli3; gli3; proliferation ... See more keywords
GLI3 Promotes Invasion and Predicts Poor Prognosis in Colorectal Cancer
Sign Up to like & getrecommendations! Published in 2021 at "BioMed Research International"
DOI: 10.1155/2021/8889986
Abstract: Purpose The epithelial–mesenchymal transition (EMT) is a key hallmark of cancer which promotes malignant progression, especially during the process of cancer invasion. A better understanding of EMT will help elucidate the molecular mechanism underlying colorectal… read more here.
Keywords: emt; invasion; gli3; colorectal cancer ... See more keywords
GLI3 Is Stabilized by SPOP Mutations and Promotes Castration Resistance via Functional Cooperation with Androgen Receptor in Prostate Cancer
Sign Up to like & getrecommendations! Published in 2021 at "Molecular Cancer Research"
DOI: 10.1158/1541-7786.mcr-21-0108
Abstract: Although the Sonic hedgehog (SHH) signaling pathway has been implicated in promoting malignant phenotypes of prostate cancer, details on how it is activated and exerts its oncogenic role during prostate cancer development and progression is… read more here.
Keywords: gli3; cancer; prostate cancer; castration ... See more keywords
Counter-Balance Between Gli3 and miR-7 Is Required for Proper Morphogenesis and Size Control of the Mouse Brain
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Cellular Neuroscience"
DOI: 10.3389/fncel.2018.00259
Abstract: Brain morphogenesis requires precise regulation of multiple genes to control specification of distinct neural progenitors (NPs) and neuronal production. Dysregulation of these genes results in severe brain malformation such as macrocephaly and microcephaly. Despite studies… read more here.
Keywords: counter balance; mir; gli3; morphogenesis ... See more keywords
Regulation of Calvarial Osteogenesis by Concomitant De-repression of GLI3 and Activation of IHH Targets
Sign Up to like & getrecommendations! Published in 2017 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2017.01036
Abstract: Loss-of-function mutations in GLI3 and IHH cause craniosynostosis and reduced osteogenesis, respectively. In this study, we show that Ihh ligand, the receptor Ptch1 and Gli transcription factors are differentially expressed in embryonic mouse calvaria osteogenic… read more here.
Keywords: ihh; runx2; ligand; gli3 ... See more keywords
GANT61 and Lithium Chloride Inhibit the Growth of Head and Neck Cancer Cell Lines Through the Regulation of GLI3 Processing by GSK3β
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms21176410
Abstract: Several signaling pathways are aberrantly activated in head and neck squamous cell carcinoma (HNSCC), including the Hedgehog-Gli (HH-GLI), WNT, EGFR, and NOTCH pathways. The HH-GLI pathway has mostly been investigated in the context of canonical… read more here.
Keywords: cell lines; gli3; lithium chloride; gant61 lithium ... See more keywords