In vivo glia‐to‐neuron conversion: pitfalls and solutions
Sign Up to like & getrecommendations! Published in 2022 at "Developmental Neurobiology"
DOI: 10.1002/dneu.22880
Abstract: Neuron loss and disruption of neural circuits are associated with many neurological conditions. A key question is how to rebuild neural circuits for functional improvements. In vivo glia‐to‐neuron (GtN) conversion emerges as a potential solution… read more here.
Keywords: glia neuron; conversion pitfalls; neuron conversion; vivo glia ... See more keywords
Genetic variation in glia–neuron signalling modulates ageing rate
Sign Up to like & getrecommendations! Published in 2017 at "Nature"
DOI: 10.1038/nature24463
Abstract: The rate of behavioural decline in the ageing population is remarkably variable among individuals. Despite the considerable interest in studying natural variation in ageing rate to identify factors that control healthy ageing, no such factor… read more here.
Keywords: variation; glia neuron; ageing rate; neuron signalling ... See more keywords
The special relationship: glia–neuron interactions in the neuroendocrine hypothalamus
Sign Up to like & getrecommendations! Published in 2018 at "Nature Reviews Endocrinology"
DOI: 10.1038/nrendo.2017.124
Abstract: Natural fluctuations in physiological conditions require adaptive responses involving rapid and reversible structural and functional changes in the hypothalamic neuroendocrine circuits that control homeostasis. Here, we discuss the data that implicate hypothalamic glia in the… read more here.
Keywords: glia neuron; special relationship; relationship glia; hypothalamic neuroendocrine ... See more keywords
Glia to neuron ratio in the posterior aspect of the human spinal cord at thoracic segments relevant to spinal cord stimulation
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Anatomy"
DOI: 10.1111/joa.13061
Abstract: Spinal cord stimulation (SCS) applied between T8 and T11 segments has been shown to be effective for the treatment of chronic pain of the lower back and limbs. However, the mechanism of the analgesic effect… read more here.
Keywords: glial cells; matter; cord; glia neuron ... See more keywords
Ectopic insert-dependent neuronal expression of GFAP promoter-driven AAV constructs in adult mouse retina
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.914386
Abstract: Direct reprogramming of retinal Müller glia is a promising avenue for replacing photoreceptors and retinal ganglion cells lost to retinal dystrophies. However, questions have recently been raised about the accuracy of studies claiming efficient glia-to-neuron… read more here.
Keywords: promoter; glia neuron; driven aav; retina ... See more keywords
Role of Extracellular Vesicles in Glia-Neuron Intercellular Communication
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Molecular Neuroscience"
DOI: 10.3389/fnmol.2022.844194
Abstract: Cross talk between glia and neurons is crucial for a variety of biological functions, ranging from nervous system development, axonal conduction, synaptic transmission, neural circuit maturation, to homeostasis maintenance. Extracellular vesicles (EVs), which were initially… read more here.
Keywords: role extracellular; glia neuron; intercellular communication; extracellular vesicles ... See more keywords
Targeting PTB for Glia-to-Neuron Reprogramming In Vitro and In Vivo for Therapeutic Development in Neurological Diseases
Sign Up to like & getrecommendations! Published in 2022 at "Biomedicines"
DOI: 10.3390/biomedicines10020399
Abstract: In vivo cell reprogramming of glial cells offers a promising way to generate new neurons in the adult mammalian nervous system. This approach might compensate for neuronal loss occurring in neurological disorders, but clinically viable… read more here.
Keywords: neuron reprogramming; glia neuron; targeting ptb; reprogramming vitro ... See more keywords