Brain glial activation in fibromyalgia – A multi-site positron emission tomography investigation
Sign Up to like & getrecommendations! Published in 2019 at "Brain, Behavior, and Immunity"
DOI: 10.1016/j.bbi.2018.09.018
Abstract: Fibromyalgia (FM) is a poorly understood chronic condition characterized by widespread musculoskeletal pain, fatigue, and cognitive difficulties. While mounting evidence suggests a role for neuroinflammation, no study has directly provided evidence of brain glial activation… read more here.
Keywords: glial activation; signal; brain; 11c pbr28 ... See more keywords
BRD4 suppression alleviates cerebral ischemia-induced brain injury by blocking glial activation via the inhibition of inflammatory response and pyroptosis.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2019.07.097
Abstract: Ischemic stroke is a major cause of death and disability worldwide. Hyperneuroinflammation significantly contributes to ischemic stroke. Bromodomain-containing protein 4 (BRD4) is a member of the Bromo and Extra-Terminal (BET) family, and promotes inflammatory response… read more here.
Keywords: glial activation; inhibition; brain; expression ... See more keywords
Acute administration of sulfur-doped g-C3N4 induces cognitive deficits and exacerbates the levels of glial activation in mouse hippocampus
Sign Up to like & getrecommendations! Published in 2021 at "Brain Research Bulletin"
DOI: 10.1016/j.brainresbull.2021.08.006
Abstract: During the last decades, graphitic carbon nitride (g-C3N4) has attracted increasing attention in several biomedical fields. In this study, the effects of sulfur-doped g-C3N4 (TCN) on cognitive function and histopathology of hippocampus were investigated in… read more here.
Keywords: glial activation; hippocampus; microscopy; spectroscopy ... See more keywords
Hesperetin reduces myelin damage and ameliorates glial activation in lysolecithin‐induced focal demyelination model of rat optic chiasm
Sign Up to like & getrecommendations! Published in 2018 at "Life Sciences"
DOI: 10.1016/j.lfs.2018.07.001
Abstract: ABSTRACT Visual impairment is considered as the most common initial manifestation of multiple sclerosis (MS) patients. It has been shown that hesperetin (Hst), a flavonoid of citrus fruit, possesses anti‐inflammatory and antioxidant effects both in… read more here.
Keywords: demyelination; hst; glial activation; optic chiasm ... See more keywords
Glial activation positron emission tomography imaging in radiation treatment of breast cancer brain metastases
Sign Up to like & getrecommendations! Published in 2022 at "Physics and Imaging in Radiation Oncology"
DOI: 10.1016/j.phro.2022.02.016
Abstract: Brain metastases affect more breast cancer patients than ever before due to increased overall patient survival with improved molecularly targeted treatments. Approximately 25–34% of breast cancer patients develop brain metastases in their lifetime. Due to… read more here.
Keywords: cancer; brain metastases; radiation; glial activation ... See more keywords
Oleoylethanolamide inhibits glial activation via moudulating PPAR&agr; and promotes motor function recovery after brain ischemia
Sign Up to like & getrecommendations! Published in 2019 at "Pharmacological Research"
DOI: 10.1016/j.phrs.2019.01.027
Abstract: &NA; Glial activation and scar formation impede the neurological function recovery after cerebral ischemia. Oleoylethanolamide (OEA), a bioactive lipid mediator, shows neuroprotection against acute brain ischemia, however, its long‐term effect, especially on glial scar formation,… read more here.
Keywords: motor function; glial activation; ppar agr; brain ischemia ... See more keywords
Curcumin-loaded chitosan-alginate-STPP nanoparticles ameliorate memory deficits and reduce glial activation in pentylenetetrazol-induced kindling model of epilepsy
Sign Up to like & getrecommendations! Published in 2017 at "Progress in Neuro-Psychopharmacology and Biological Psychiatry"
DOI: 10.1016/j.pnpbp.2017.07.025
Abstract: Despite several beneficial effects of curcumin, its medical application has been hampered due to low water solubility. To improve the aqueous solubility of curcumin, it has been loaded on chitosan (CS)-alginate (ALG) - sodium tripolyphosphate… read more here.
Keywords: glial activation; curcumin nps; model; memory ... See more keywords
CCAAT/Enhancer binding protein β silencing mitigates glial activation and neurodegeneration in a rat model of Parkinson’s disease
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-13269-4
Abstract: The CCAAT/Enhancer binding protein β (C/EBPβ) is a transcription factor involved in numerous physiological as well as pathological conditions in the brain. However, little is known regarding its possible role in neurodegenerative disorders. We have… read more here.
Keywords: enhancer binding; ccaat enhancer; glial activation; parkinson disease ... See more keywords
Glial activation in prion diseases is selectively triggered by neuronal PrPSc.
Sign Up to like & getrecommendations! Published in 2022 at "Brain pathology"
DOI: 10.1111/bpa.13056
Abstract: Although prion infections cause cognitive impairment and neuronal death, transcriptional and translational profiling shows progressive derangement within glia but surprisingly little changes within neurons. Here we expressed PrPC selectively in neurons and astrocytes of mice.… read more here.
Keywords: prion diseases; diseases selectively; prpsc; prion ... See more keywords
Acetylcholinesterase inhibition ameliorates retinal neovascularization and glial activation in oxygen-induced retinopathy.
Sign Up to like & getrecommendations! Published in 2020 at "International journal of ophthalmology"
DOI: 10.18240/ijo.2020.09.04
Abstract: AIM To investigate whether inhibition of acetylcholinesterase (AChE) by donepezil ameliorate aberrant retinal neovascularization (RNV) and abnormal glial activation in oxygen-induced retinopathy (OIR). METHODS A mouse model of RNV was induced in postnatal day 7… read more here.
Keywords: oxygen; ache; glial activation; inhibition ... See more keywords
Glial Activation Markers in CSF and Serum From Patients With Primary Progressive Multiple Sclerosis: Potential of Serum GFAP as Disease Severity Marker?
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Neurology"
DOI: 10.3389/fneur.2019.00280
Abstract: Background: In progressive multiple sclerosis (MS), glial activation is thought to be a relevant mechanism of disability progression. Therefore, in vivo assessment of the glial cell activity is, in the emerging treatment era of primary… read more here.
Keywords: csf serum; severity; glial activation; disease ... See more keywords