Glial changes and gene expression in Alzheimer's disease from snRNA-Seq and spatial transcriptomics
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Alzheimer's Disease"
DOI: 10.1177/13872877251330320
Abstract: Background Alzheimer's disease (AD) is characterized by cortical atrophy, glutamatergic neuron loss, and cognitive decline. However, large-scale quantitative assessments of cellular changes during AD pathology remain scarce. Objective This study aims to integrate single-nuclei sequencing… read more here.
Keywords: alzheimer disease; disease; spatial transcriptomics; glial changes ... See more keywords
Retinal Tissue Shows Glial Changes in a Dravet Syndrome Knock-in Mouse Model
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DOI: 10.3390/ijms24032727
Abstract: Dravet syndrome (DS) is an epileptic encephalopathy caused by mutations in the Scn1a gene encoding the α1 subunit of the Nav1.1 sodium channel, which is associated with recurrent and generalized seizures, even leading to death.… read more here.
Keywords: tissue shows; dravet syndrome; model; retinal tissue ... See more keywords
Glial changes in schizophrenia: Genetic and epigenetic approach
Sign Up to like & getrecommendations! Published in 2022 at "Indian Journal of Psychiatry"
DOI: 10.4103/indianjpsychiatry.indianjpsychiatry_104_21
Abstract: Background: Schizophrenia (SCZ) is a severe mental illness that affects one percent of the population, affecting how people think, feel, and behave. Evidence suggests glial cell alteration and some researchers have found genetic risk loci… read more here.
Keywords: schizophrenia genetic; epigenetic approach; changes schizophrenia; evidence ... See more keywords