Severe Hippocampal Atrophy in a Patient With Autoimmune Glial Fibrillary Acidic Protein Astrocytopathy.
Sign Up to like & getrecommendations! Published in 2023 at "JAMA neurology"
DOI: 10.1001/jamaneurol.2023.0606
Abstract: This case report describes a patient who presented with headache, fever, quadriparesis, and reduced visual acuity in the left eye and 6 months later presented with persistent quadriparesis and new-onset cognitive deficits. read more here.
Keywords: severe hippocampal; hippocampal atrophy; patient autoimmune; glial fibrillary ... See more keywords
Serum levels of glial fibrillary acidic protein in patients with amyotrophic lateral sclerosis
Sign Up to like & getrecommendations! Published in 2022 at "Annals of Clinical and Translational Neurology"
DOI: 10.1002/acn3.51708
Abstract: To compare serum levels of the astrocyte biomarker glial fibrillary acidic protein (GFAP) in patients with amyotrophic lateral sclerosis (ALS) and neurologically healthy controls and to analyze the relations between serum GFAP (sGFAP) and phenotype… read more here.
Keywords: patients amyotrophic; fibrillary acidic; serum levels; acidic protein ... See more keywords
A 14‐Year Study of Serum Glial Fibrillary Acidic Protein and Total Tau in Premanifest Huntington's
Sign Up to like & getrecommendations! Published in 2025 at "Annals of Clinical and Translational Neurology"
DOI: 10.1002/acn3.70057
Abstract: There is a pressing need for blood biomarkers that can identify Huntington's disease (HD) gene carriers' proximity to manifest disease. We previously examined serial serum neurofilament light (NfL) concentrations in 21 premanifest HD gene carriers… read more here.
Keywords: acidic protein; glial fibrillary; fibrillary acidic; protein total ... See more keywords
Glial Fibrillary Acidic Protein Astrocytopathy Based on a Two‐Center Chinese Cohort Study
Sign Up to like & getrecommendations! Published in 2025 at "Annals of Clinical and Translational Neurology"
DOI: 10.1002/acn3.70118
Abstract: Glial fibrillary acidic protein astrocytopathy (GFAP‐A) is a recently defined nosological form belonging to the class of autoimmune inflammatory disorders affecting the central nervous system (CNS). Here, we report the clinical and MRI characteristics, treatment,… read more here.
Keywords: acidic protein; glial fibrillary; fibrillary acidic; protein astrocytopathy ... See more keywords
Assessment of Glial Fibrillary Acidic Protein Binding to the Surface of Leukocytes with Dark‐Field Imaging and Computational Analysis
Sign Up to like & getrecommendations! Published in 2021 at "Advanced Functional Materials"
DOI: 10.1002/adfm.202009229
Abstract: The glial fibrillary acidic protein (GFAP) is widely established as a traumatic brain injury (TBI) biomarker and can be used in early diagnosis. As essential primary human immune cells, leukocytes are recruited to injured cerebral… read more here.
Keywords: glial fibrillary; field; field imaging; acidic protein ... See more keywords
Serum Glial Fibrillary Acidic Protein: A Neuromyelitis Optica Spectrum Disorder Biomarker
Sign Up to like & getrecommendations! Published in 2021 at "Annals of Neurology"
DOI: 10.1002/ana.26067
Abstract: Blood tests to monitor disease activity, attack severity, or treatment impact in neuromyelitis optica spectrum disorder (NMOSD) have not been developed. This study investigated the relationship between serum glial fibrillary acidic protein (sGFAP) concentration and… read more here.
Keywords: serum glial; spectrum disorder; fibrillary acidic; neuromyelitis optica ... See more keywords
Autoimmune Glial Fibrillary Acidic Protein Astrocytopathy Is Associated with HLA‐A*3303 and HLA‐DPB1*0501
Sign Up to like & getrecommendations! Published in 2024 at "Annals of Neurology"
DOI: 10.1002/ana.26899
Abstract: We determined the genetic association between specific human leucocyte antigen (HLA) loci and autoimmune glial fibrillary acidic protein (GFAP) astrocytopathy. Our results showed that autoimmune GFAP astrocytopathy was associated with HLA‐A*3303 (odds ratio [OR] = 2.02, 95%… read more here.
Keywords: acidic protein; hla; glial fibrillary; hla 3303 ... See more keywords
Neurochemical regulation of the expression and function of glial fibrillary acidic protein in astrocytes
Sign Up to like & getrecommendations! Published in 2019 at "Glia"
DOI: 10.1002/glia.23734
Abstract: Glial fibrillary acidic protein (GFAP), a type III intermediate filament, is a marker of mature astrocytes. The expression of GFAP gene is regulated by many transcription factors (TFs), mainly Janus kinase‐2/signal transducer and activator of… read more here.
Keywords: fibrillary acidic; acidic protein; expression; glial fibrillary ... See more keywords
Ezrin deficiency triggers glial fibrillary acidic protein upregulation and a distinct reactive astrocyte phenotype
Sign Up to like & getrecommendations! Published in 2022 at "Glia"
DOI: 10.1002/glia.24253
Abstract: Astrocytes are increasingly being recognized as contributors to physiological brain function and behavior. Astrocytes engage in glia‐synaptic interactions through peripheral astrocyte processes, thus modulating synaptic signaling, for example, by handling glutamate removal from the synaptic… read more here.
Keywords: fibrillary acidic; ezrin; protein upregulation; acidic protein ... See more keywords
New insights into neuropathology and pathogenesis of autoimmune glial fibrillary acidic protein meningoencephalomyelitis
Sign Up to like & getrecommendations! Published in 2024 at "Acta Neuropathologica"
DOI: 10.1007/s00401-023-02678-7
Abstract: Anti-glial fibrillary acidic protein (GFAP) meningoencephalomyelitis (autoimmune GFAP astrocytopathy) is a new autoimmune central nervous system (CNS) disease diagnosable by the presence of anti-GFAP autoantibodies in the cerebrospinal fluid and presents as meningoencephalomyelitis in the… read more here.
Keywords: acidic protein; glial fibrillary; fibrillary acidic; gfap ... See more keywords
Reliability of serum neurofilament light and glial fibrillary acidic protein for detecting disease activity upon discontinuation of first-line disease-modifying therapy in stable multiple sclerosis (DOT-MS)
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Neurology"
DOI: 10.1007/s00415-025-13231-9
Abstract: Background Neurofilament light(NfL) and glial fibrillary acidic protein(GFAP) are associated with disease activity in multiple sclerosis(MS), however use in monitoring remains limited. The ability of these biomarkers to detect disease activity upon treatment discontinuation was… read more here.
Keywords: disease; disease activity; neurofilament light; glial fibrillary ... See more keywords