Knockout of transient receptor potential ankyrin 1 (TRPA1) modulates the glial phenotype and alleviates perihematomal neuroinflammation after intracerebral hemorrhage in mice via MAPK/NF-κB signaling
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DOI: 10.1097/wnr.0000000000001862
Abstract: The objective is to explore the role of astrocytic transient receptor potential ankyrin 1 (TRPA1) in glial phenotype transformation in neuroinflammation after intracerebral hemorrhage (ICH). Wild-type astrocytes and TRPA1−/− astrocytes were subjected to 6-h hemin… read more here.
Keywords: trpa1; ich mice; neuroinflammation; mice ... See more keywords
Glial phenotype modulators
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DOI: 10.18632/oncotarget.16245
Abstract: Neuroinflammation is an important component of many neuroinflammatory and neurodegenerative diseases. Microglia and astrocytes play a key role in neuroinflammation. Activated glial cells under neuroinflammatory condition produce proinflammatory cytokines, chemokines, nitric oxide (NO), and other… read more here.
Keywords: phenotype; ppar; gpm; glial phenotype ... See more keywords