The formation of a glial scar does not prohibit remyelination in an animal model of multiple sclerosis
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DOI: 10.1002/glia.23556
Abstract: The role of astrocytes in the pathophysiology of multiple sclerosis (MS) is discussed controversially. Especially the formation of the glial scar is often believed to act as a barrier for remyelination. At the same time,… read more here.
Keywords: remyelination; glial scar; multiple sclerosis; animal model ... See more keywords
Inhibitory role of lentivirus‐mediated aquaporin‐4 gene silencing in the formation of glial scar in a rat model of traumatic brain injury
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.27390
Abstract: Traumatic brain injury (TBI), an acute degenerative pathology of the central nervous system, is a leading cause of death and disability. As the glial scar is a mechanical barrier to nerve regeneration, inhibitory molecules in… read more here.
Keywords: scar; traumatic brain; glial scar; gene silencing ... See more keywords
TGN‐020 alleviates edema and inhibits astrocyte activation and glial scar formation after spinal cord compression injury in rats
Sign Up to like & getrecommendations! Published in 2019 at "Life Sciences"
DOI: 10.1016/j.lfs.2019.03.007
Abstract: Aims: Identifying drugs that inhibit edema and glial scar formation and increase neuronal survival is crucial to improving outcomes after spinal cord injury (SCI). Here, we used 2‐(nicotinamide)‐1,3,4‐thiadiazole (TGN‐020), a potent selective inhibitor of aquaporin… read more here.
Keywords: glial scar; spinal cord; scar formation; tgn 020 ... See more keywords
Astrocyte reactivity and astrogliosis after spinal cord injury
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DOI: 10.1016/j.neures.2017.10.004
Abstract: After traumatic injuries of the central nervous system (CNS), including spinal cord injury (SCI), astrocytes surrounding the lesion become reactive and typically undergo hypertrophy and process extension. These reactive astrocytes migrate centripetally to the lesion… read more here.
Keywords: glial scar; injury; cord injury; spinal cord ... See more keywords
Valproic Acid Inhibits Glial Scar Formation after Ischemic Stroke
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DOI: 10.1159/000514951
Abstract: Introduction: Cerebral ischemia induces reactive proliferation of astrocytes (astrogliosis) and glial scar formation. As a physical and biochemical barrier, the glial scar not only hinders spontaneous axonal regeneration and neuronal repair but also deteriorates the… read more here.
Keywords: scar; scar formation; ischemic stroke; glial scar ... See more keywords
Protease-activated receptor-2 regulates glial scar formation via JNK signaling.
Sign Up to like & getrecommendations! Published in 2019 at "Physiological research"
DOI: 10.33549/physiolres.933908
Abstract: The study aimed to determine the effects of protease-activated receptor-2 (PAR-2) on glial scar formation after spinal cord injury (SCI) in Sprague-Dawley (SD) rats and the underlying mechanisms. Rivlin and Tator's acute extradural clip compression… read more here.
Keywords: glial scar; par; scar formation; jnk ... See more keywords
Rapamycin Preserves Neural Tissue, Promotes Schwann Cell Myelination and Reduces Glial Scar Formation After Hemi-Contusion Spinal Cord Injury in Mice
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Molecular Neuroscience"
DOI: 10.3389/fnmol.2020.574041
Abstract: Protecting white matter is one of the key treatment strategies for spinal cord injury (SCI), including alleviation of myelin loss and promotion of remyelination. Rapamycin has been shown neuroprotective effects against SCI and cardiotoxic effects… read more here.
Keywords: sci; contusion; glial scar; mice ... See more keywords
The Composition and Cellular Sources of CSPGs in the Glial Scar After Spinal Cord Injury in the Lamprey
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DOI: 10.3389/fnmol.2022.918871
Abstract: Axon regrowth after spinal cord injury (SCI) is inhibited by several types of inhibitory extracellular molecules in the central nervous system (CNS), including chondroitin sulfate proteoglycans (CSPGs), which also are components of perineuronal nets (PNNs).… read more here.
Keywords: cord; sci; cord injury; spinal cord ... See more keywords
M2 microglial small extracellular vesicles reduce glial scar formation via the miR-124/STAT3 pathway after ischemic stroke in mice
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DOI: 10.7150/thno.48761
Abstract: Rationale: Glial scars present a major obstacle for neuronal regeneration after stroke. Thus, approaches to promote their degradation and inhibit their formation are beneficial for stroke recovery. The interaction of microglia and astrocytes is known… read more here.
Keywords: extracellular vesicles; glial scar; microglial small; formation ... See more keywords