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Published in 2018 at "Journal of Pharmaceutical and Biomedical Analysis"
DOI: 10.1016/j.jpba.2018.03.025
Abstract: HIGHLIGHTSGlibenclamide interacts with DNA through groove binding.The spectrometric and electrochemical studies reveal direct interaction of Glibenclamide with DNA.The interaction between Glibenclamide and B‐form of DNA is thermodynamically favorable.Glibenclamide synergistically enhances the cytotoxicity of Doxorubicin against…
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Keywords:
glibenclamide;
dna;
spectroscopy;
interaction ... See more keywords
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Published in 2019 at "Microchemical Journal"
DOI: 10.1016/j.microc.2019.05.009
Abstract: Abstract In the present study, Glibenclamide (GLI) was determined in blood samples through the application of a method based on coupling low-voltage electromembrane extraction (LV-EME) and fast Fourier transform square wave voltammetry (FFTSWV). The parameters…
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Keywords:
glibenclamide;
low voltage;
blood;
voltage ... See more keywords
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Published in 2020 at "Neuropharmacology"
DOI: 10.1016/j.neuropharm.2019.107845
Abstract: Glibenclamide protects against ischemic injury in both preclinical and clinical studies, presumably by blocking the de novo assembled sulfonylurea receptor 1-transient receptor potential M4 (Sur1-Trpm4) channel induced by ischemia. However, glibenclamide may cause unexpected serious…
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Keywords:
glibenclamide;
ischemic stroke;
comparable efficacy;
mice ... See more keywords
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Published in 2017 at "RSC Advances"
DOI: 10.1039/c7ra03042h
Abstract: We investigated the anti-neuroinflammatory activity and mechanism of glibenclamide, sulfonylurea receptor 1 (Sur1) antagonist, against LPS-induced microglial activation in vitro. BV2 microglia cells were exposed to LPS (100 ng mL−1). iNOS and COX-2 levels, proinflammatory…
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Keywords:
p38 mapk;
glibenclamide;
lps induced;
antagonist ... See more keywords
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Published in 2018 at "International Journal of Analytical Chemistry"
DOI: 10.1155/2018/2569027
Abstract: Quick and specific bioanalytical methods are required for analyzing drugs in biological samples. A simple, quick, sensitive, and specific UPLC-MS/MS method was developed and validated for glibenclamide determination in plasma samples. The plasma samples were…
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Keywords:
glibenclamide;
plasma;
uplc method;
rapid validated ... See more keywords
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Published in 2017 at "Cellular Physiology and Biochemistry"
DOI: 10.1159/000477117
Abstract: Background/Aims: The sulphonylurea glibenclamide (Gli) is widely used in the treatment of type 2 diabetes. In addition to its antidiabetic effects, low incidences of certain types of cancer have been observed in Gli-treated diabetic patients.…
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Keywords:
msg rats;
glibenclamide;
treatment;
tumour growth ... See more keywords
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Published in 2018 at "AAPS PharmSciTech"
DOI: 10.1208/s12249-018-1108-y
Abstract: In an attempt to decrease the dose, anticipated side effects, and the cost of production of glibenclamide, GLC, a potent oral hypoglycemic drug, the enhancement of the dissolution and hence the oral bioavailability were investigated.…
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Keywords:
glibenclamide;
adsorption;
oral bioavailability;
mini tablets ... See more keywords
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Published in 2017 at "PLoS Neglected Tropical Diseases"
DOI: 10.1371/journal.pntd.0006111
Abstract: Cystic echinococcosis (CE) is a worldwide parasitic zoonosis caused by the larval stage of Echinococcus granulosus. Current chemotherapy against this disease is based on the administration of benzimidazoles (BZMs). However, BZM treatment has a low…
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Keywords:
larval stage;
glibenclamide;
cystic echinococcosis;
anthelminthic activity ... See more keywords
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Published in 2021 at "PLoS ONE"
DOI: 10.1371/journal.pone.0252584
Abstract: Intracerebral hemorrhage (ICH) is a devastating insult with few effective treatments. Edema and raised intracranial pressure contribute to poor outcome after ICH. Glibenclamide blocks the sulfonylurea 1 transient receptor potential melastatin 4 (Sur1-Trpm4) channel implicated…
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Keywords:
following severe;
glibenclamide;
improve outcome;
outcome ... See more keywords
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Published in 2019 at "Biomedical Reports"
DOI: 10.3892/br.2019.1204
Abstract: The majority of Mexican patients with diabetes mellitus type 2 (DMT2) (67.9-85.0%) are prescribed sulphonylureas (SUs), which are metabolized by cytochrome P450 2C9 (abbreviated as CYP2C9). SUs are a type of oral anti-diabetic compound which…
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Keywords:
glibenclamide;
cyp2c9;
glibenclamide metformin;
metformin ... See more keywords