Induction and Assessment of Hypoxia in Glioblastoma Cells In Vitro.
Sign Up to like & getrecommendations! Published in 2018 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-7659-1_9
Abstract: To simulate and study the hypoxic microenvironment associated with intracerebral glioma in vivo, simple and reproducible methods are described and discussed for inducing hypoxia or chemical pseudohypoxia in glioma cell cultures and assessing their effects… read more here.
Keywords: glioblastoma cells; assessment hypoxia; hypoxia; cells vitro ... See more keywords
JCI-20679 suppresses autophagy and enhances temozolomide-mediated growth inhibition of glioblastoma cells.
Sign Up to like & getrecommendations! Published in 2021 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2021.12.113
Abstract: Glioblastoma, a type of brain cancer, is one of the most aggressive and lethal types of malignancy. The present study shows that JCI-20679, an originally synthesized mitochondrial complex I inhibitor, enhances the anti-proliferative effects of… read more here.
Keywords: jci 20679; glioblastoma; temozolomide mediated; cells jci ... See more keywords
Schwann cell-specific Dp116 is expressed in glioblastoma cells, revealing two novel DMD gene splicing patterns
Sign Up to like & getrecommendations! Published in 2019 at "Biochemistry and Biophysics Reports"
DOI: 10.1016/j.bbrep.2019.100703
Abstract: Background The DMD gene is one of the largest human genes, being composed of 79 exons. Dystrophin Dp116 expressed from the promoter in intron 55 is a Schwann cell-specific isoform. The pathophysiological roles of Dp116… read more here.
Keywords: dmd gene; glioblastoma; dp116 expressed; splicing patterns ... See more keywords
miR-424 induces apoptosis in glioblastoma cells and targets AKT1 and RAF1 oncogenes from the ERBB signaling pathway.
Sign Up to like & getrecommendations! Published in 2021 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2021.174273
Abstract: Glioblastoma is a lethal and incurable cancer. Tumor suppressor miRNAs are promising gene therapy tools for cancer treatment. In silico, we predicted miR-424 as a tumor suppressor. It had several target genes from the epidermal… read more here.
Keywords: mir 424; target genes; glioblastoma; tumor suppressor ... See more keywords
Role of modification route for zinc oxide nanoparticles on protein structure and their effects on glioblastoma cells.
Sign Up to like & getrecommendations! Published in 2018 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2018.06.059
Abstract: Zinc oxide nanoparticles (ZnO) are presented as potential cancer therapeutic agent based on their surface properties. In this study, the most abundant blood proteins, albumin, fibrinogen and apo-transferrin, were covalently bound (c-ZnO NPs) and nonspecifically… read more here.
Keywords: zno nps; zno; zinc oxide; structure ... See more keywords
Morphological and quantitative analysis on α-tubulin modifications in glioblastoma cells
Sign Up to like & getrecommendations! Published in 2018 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2018.09.044
Abstract: Glioblastoma is one of the primary tumors of the brain with high invasiveness and lethality. In the study of its pathophysiology in recent years much attention has been paid to the microtubular network, but exclusively… read more here.
Keywords: analysis; glioblastoma cells; tubulin; tubulin modifications ... See more keywords
Nucleolin is expressed in patient‐derived samples and glioblastoma cells, enabling improved intracellular drug delivery and cytotoxicity
Sign Up to like & getrecommendations! Published in 2018 at "Experimental Cell Research"
DOI: 10.1016/j.yexcr.2018.06.005
Abstract: ABSTRACT One of the major challenges in Glioblastoma (GBM) therapy relates with the existence of glioma stem‐like cells (GSCs), known to be chemo‐ and radio‐resistant. GSCs and non‐stem GBM cells have the ability to interchange,… read more here.
Keywords: drug delivery; derived samples; nucleolin; glioblastoma cells ... See more keywords
Investigation of Cytotoxicity and Oxidative Stress Induced by the Pyrethroid Bioallethrin in Human Glioblastoma Cells: The Protective Effect of Vitamin E (VE) and Its Underlying Mechanism.
Sign Up to like & getrecommendations! Published in 2022 at "Chemical research in toxicology"
DOI: 10.1021/acs.chemrestox.2c00033
Abstract: Bioallethrin belongs to the family of pyrethroid insecticides. Previous studies have shown that bioallethrin affected the function of muscarinic receptor and subsequently induced neurotoxicity in different brain models. Reactive oxygen species (ROS) are generated in… read more here.
Keywords: glioblastoma cells; cytotoxicity; human glioblastoma; bioallethrin ... See more keywords
Oxidative stress-dependent and -independent death of glioblastoma cells induced by non-thermal plasma-exposed solutions
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-50136-w
Abstract: Non-thermal atmospheric pressure plasma has been widely used for preclinical studies in areas such as wound healing, blood coagulation, and cancer therapy. We previously developed plasma-activated medium (PAM) and plasma-activated Ringer’s lactate solutions (PAL) for… read more here.
Keywords: plasma; non thermal; stress; cancer ... See more keywords
Activating transcription factor 4 mediates adaptation of human glioblastoma cells to hypoxia and temozolomide
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DOI: 10.1038/s41598-021-93663-1
Abstract: The integrated stress response (ISR) is a central cellular adaptive program that is activated by diverse stressors including ER stress, hypoxia and nutrient deprivation to orchestrate responses via activating transcription factor 4 (ATF4). We hypothesized… read more here.
Keywords: adaptation human; transcription factor; activating transcription; glioblastoma cells ... See more keywords
Aminobenzofuran-containing analogues of proximicins exhibit higher antiproliferative activity against human UG-87 glioblastoma cells compared to temozolomide
Sign Up to like & getrecommendations! Published in 2023 at "RSC Advances"
DOI: 10.1039/d3ra00107e
Abstract: A new series of proximicin analogues containing a benzofuran moiety as the replacement of the di-furan scaffold of the parent compound were synthesised and evaluated for their anti-proliferative activities against human glioblastoma cells U-87 MG.… read more here.
Keywords: glioblastoma cells; higher antiproliferative; glioblastoma; human glioblastoma ... See more keywords