Glioblastoma: Current Status, Emerging Targets, and Recent Advances
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Medicinal Chemistry"
DOI: 10.1021/acs.jmedchem.1c01946
Abstract: Glioblastoma (GBM) is a highly malignant brain tumor characterized by a heterogeneous population of genetically unstable and highly infiltrative cells that are resistant to chemotherapy. Although substantial efforts have been invested in the field of… read more here.
Keywords: drug discovery; chemistry; gbm drug; glioblastoma current ... See more keywords
Tumour treating fields therapy for glioblastoma: current advances and future directions
Sign Up to like & getrecommendations! Published in 2020 at "British Journal of Cancer"
DOI: 10.1038/s41416-020-01136-5
Abstract: Glioblastoma multiforme (GBM) is the most common primary brain tumour in adults and continues to portend poor survival, despite multimodal treatment using surgery and chemoradiotherapy. The addition of tumour-treating fields (TTFields)—an approach in which alternating… read more here.
Keywords: glioblastoma current; therapy glioblastoma; tumour treating; fields therapy ... See more keywords
Glioblastoma: The Current State of Biology and Therapeutic Strategies.
Sign Up to like & getrecommendations! Published in 2022 at "Cancer research"
DOI: 10.1158/0008-5472.can-21-3534
Abstract: Over the past two decades, there have been advances in surgical technologies and chemoradiation strategies for glioblastoma, yet durable remissions are rarely seen. As the biological challenges and genetic basis of glioblastoma have become more… read more here.
Keywords: therapeutic strategies; glioblastoma current; strategies glioblastoma; current state ... See more keywords
Immunotherapy in Glioblastoma: Current Shortcomings and Future Perspectives
Sign Up to like & getrecommendations! Published in 2020 at "Cancers"
DOI: 10.3390/cancers12030751
Abstract: Glioblastomas are aggressive, fast-growing primary brain tumors. After standard-of-care treatment with radiation in combination with temozolomide, the overall prognosis of newly diagnosed patients remains poor, with a 2-year survival rate of less than 20%. The… read more here.
Keywords: immunotherapy glioblastoma; glioblastoma current; future perspectives; shortcomings future ... See more keywords
Immunotherapy for Glioblastoma: Current State, Challenges, and Future Perspectives
Sign Up to like & getrecommendations! Published in 2020 at "Cancers"
DOI: 10.3390/cancers12092334
Abstract: Glioblastoma is the most lethal intracranial primary malignancy by no optimal treatment option. Cancer immunotherapy has achieved remarkable survival benefits against various advanced tumors, such as melanoma and non-small-cell lung cancer, thus triggering great interest… read more here.
Keywords: immunotherapy glioblastoma; glioblastoma current; immunotherapy; glioblastoma ... See more keywords