Unintended effects of proton pump inhibitors (PPIs) in patients with glioblastoma (GBM): A double-edged sword
Sign Up to like & getrecommendations! Published in 2022 at "Neuro-Oncology Practice"
DOI: 10.1093/nop/npac035
Abstract: A vast literature demonstrates that aldehyde dehydrogenase-1A1 (ALDH1A1) mediates therapy resistance and is associated with poor prognosis across human cancers. In glioblastoma (GBM), ALDH1A1 expression above vs below the mean causes temozolomide and radiation resistance… read more here.
Keywords: pump inhibitors; proton pump; inhibitors ppis; glioblastoma gbm ... See more keywords
Clinical features associated with the efficacy of chemotherapy in patients with glioblastoma (GBM): a surveillance, epidemiology, and end results (SEER) analysis
Sign Up to like & getrecommendations! Published in 2021 at "BMC Cancer"
DOI: 10.1186/s12885-021-07800-0
Abstract: Background Glioblastoma (GBM) is a highly malignant brain tumor with poor survival and prognosis. Randomized trials have demonstrated that chemotherapy improves survival in patients with GBM. This study aims to examine the clinical characteristics that… read more here.
Keywords: glioblastoma gbm; epidemiology; associated efficacy; efficacy chemotherapy ... See more keywords
Effect of dexamethasone in glioblastoma (GBM) patients on systemic and intratumoral T-cell responses induced by personalized neoantigen-targeting vaccine.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2018.36.15_suppl.2020
Abstract: 2020Background: The impact of individualized neoepitope vaccination targeting neoantigens arising from tumor-specific mutations for GBM, a low mutation burden tumor with an immunologically cold tum... read more here.
Keywords: glioblastoma gbm; dexamethasone glioblastoma; gbm patients; patients systemic ... See more keywords
Repression of PCGF1 Decreases the Proliferation of Glioblastoma Cells in Association with Inactivation of c-Myc Signaling Pathway
Sign Up to like & getrecommendations! Published in 2020 at "OncoTargets and therapy"
DOI: 10.2147/ott.s234517
Abstract: Purpose Glioblastoma (GBM) is the most common primary brain tumor with a poor therapeutic outcome. Polycomb group factor 1 (PCGF1), a member of the PcG (Polycomb group) family, is highly expressed in the developing nervous… read more here.
Keywords: pcgf1; glioblastoma gbm; proliferation; myc ... See more keywords
Mitochondrial DNA Alterations in Glioblastoma (GBM)
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DOI: 10.3390/ijms22115855
Abstract: Glioblastoma (GBM) is an extremely aggressive tumor originating from neural stem cells of the central nervous system, which has high histopathological and genomic diversity. Mitochondria are cellular organelles associated with the regulation of cellular metabolism,… read more here.
Keywords: glioblastoma gbm; dna; alterations glioblastoma; mitochondrial dna ... See more keywords