Astrocytes enhance glioblastoma growth
Sign Up to like & getrecommendations! Published in 2019 at "Glia"
DOI: 10.1002/glia.23718
Abstract: Glioblastoma (GBM) is a deadly disease with a need for deeper understanding and new therapeutic approaches. The microenvironment of glioblastoma has previously been shown to guide glioblastoma progression. In this study, astrocytes were investigated with… read more here.
Keywords: glioblastoma; gbm; enhance glioblastoma; glioblastoma growth ... See more keywords
Isoprenylcysteine carboxyl methyltransferase is critical for glioblastoma growth and survival by activating Ras/Raf/Mek/Erk
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Chemotherapy and Pharmacology"
DOI: 10.1007/s00280-022-04401-x
Abstract: The poor outcomes in glioblastoma necessitate new therapeutic target. Isoprenylcysteine carboxyl methyltransferase (ICMT), a unique enzyme of the final step of prenylation that modifies activities of oncogenic proteins, represents a promising target for many cancers.… read more here.
Keywords: glioblastoma; ras raf; glioblastoma growth; mek erk ... See more keywords
Heterogeneity of glioblastoma with gliomatosis cerebri growth pattern on diffusion and perfusion MRI
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Neuro-Oncology"
DOI: 10.1007/s11060-018-03068-w
Abstract: Background and purposeGliomatosis cerebri (GC) is a rare growth pattern of glioblastoma whose diffuse nature is reflected by unspecific, relatively uniform findings on conventional MRI. In the present study we sought to evaluate the additional… read more here.
Keywords: growth pattern; glioblastoma growth; growth; diffusion ... See more keywords
Biochanin A Inhibits Glioblastoma Growth via Restricting Glycolysis and Mitochondrial Oxidative Phosphorylation
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2021.652008
Abstract: Abnormal metabolism serves a critical role in glioblastoma (GBM). Biochanin A (BCA), a flavonoid phenolic compound found in edible and herbal plants, has antioxidative and antitumor activities. However, it remains unclear whether BCA has an… read more here.
Keywords: biochanin inhibits; glycolysis; bca; inhibits glioblastoma ... See more keywords
Diosmin Inhibits Glioblastoma Growth through Inhibition of Autophagic Flux
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DOI: 10.3390/ijms221910453
Abstract: Diosmin, a natural flavone glycoside acquired through dehydrogenation of the analogous flavanone glycoside hesperidin, is plentiful in many citrus fruits. Glioblastoma multiforme (GBM) is the most malignant primary brain tumor; the average survival time of… read more here.
Keywords: inhibits glioblastoma; autophagic flux; glioblastoma growth; growth ... See more keywords
Downregulation of SYT7 inhibits glioblastoma growth by promoting cellular apoptosis.
Sign Up to like & getrecommendations! Published in 2017 at "Molecular medicine reports"
DOI: 10.3892/mmr.2017.7723
Abstract: Synaptotagmin‑7 (SYT7) is a member of the synaptotagmin gene family, and encodes a protein that mediates the calcium‑dependent regulation of membrane trafficking during synaptic transmission. A previous study demonstrated that the expression of SYT7 is… read more here.
Keywords: cellular apoptosis; growth promoting; syt7; glioblastoma growth ... See more keywords