The efficacy and toxicity of ATM inhibition in glioblastoma initiating cells-driven tumor models.
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DOI: 10.1016/j.critrevonc.2019.04.015
Abstract: The Ataxia Telangiectasia Mutated (ATM)-mediated DNA damage response (DDR) is a major mechanism of resistance of glioblastoma (GB) - initiating cells (GICs) to radiotherapy. The closely related Ataxia Telangiectasia and Rad3-related protein (ATR) is also… read more here.
Keywords: toxicity; tumor; initiating cells; inhibition ... See more keywords