A novel serum extracellular vesicle protein signature to monitor glioblastoma tumor progression
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Cancer"
DOI: 10.1002/ijc.34261
Abstract: Detection of tumor progression in patients with glioblastoma remains a major challenge. Extracellular vesicles (EVs) are potential biomarkers and can be detected in the blood of patients with glioblastoma. In our study, we evaluated the… read more here.
Keywords: tumor progression; tumor; serum; glioblastoma patients ... See more keywords
Radiographic patterns of progression with associated outcomes after bevacizumab therapy in glioblastoma patients
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Neuro-Oncology"
DOI: 10.1007/s11060-017-2550-5
Abstract: Treatment response and survival after bevacizumab failure remains poor in patients with glioblastoma. Several recent publications examining glioblastoma patients treated with bevacizumab have described specific radiographic patterns of disease progression as correlating with outcome. This… read more here.
Keywords: radiographic patterns; bevacizumab; patterns progression; progression ... See more keywords
Palliative care of older glioblastoma patients in neurosurgery
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Neuro-Oncology"
DOI: 10.1007/s11060-022-03985-x
Abstract: The care of older neurosurgical patients at the end life is a particularly demanding challenge. Especially, the specific needs of very old patients with glioblastoma at the end of life are at risk of being… read more here.
Keywords: palliative care; glioblastoma patients; care older; care ... See more keywords
Diagnostic utility of restriction spectrum imaging (RSI) in glioblastoma patients after concurrent radiation-temozolomide treatment: A pilot study
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Clinical Neuroscience"
DOI: 10.1016/j.jocn.2018.09.008
Abstract: Discriminating between tumor recurrence and treatment effects in glioblastoma patients undergoing radiation-temozolomide (RT/TMZ) therapy remains a major clinical challenge. Here, we report a pilot study to determine the utility of restriction spectrum imaging (RSI), an… read more here.
Keywords: recurrence; utility; treatment; tumor recurrence ... See more keywords
DNA Methylation subclass Receptor Tyrosine Kinase II (RTK II) is predictive for seizure development in glioblastoma patients.
Sign Up to like & getrecommendations! Published in 2022 at "Neuro-oncology"
DOI: 10.1093/neuonc/noac108
Abstract: BACKGROUND Seizures can present at any time before or after the diagnosis of a glioma. Roughly, 25-30 % of glioblastoma (GBM) patients initially present with seizures, and an additional 30 % develop seizures during the… read more here.
Keywords: methylation; seizure; rtk; glioblastoma patients ... See more keywords
PATH-28. ANGIOTENSINOGEN PROMOTER METHYLATION TO PREDICT BEVACIZUMAB RESPONSE IN RECURRENT GLIOBLASTOMA PATIENTS
Sign Up to like & getrecommendations! Published in 2019 at "Neuro-Oncology"
DOI: 10.1093/neuonc/noz175.624
Abstract: Recurrent glioblastoma patients achieving response to bevacizumab combination therapy have clinical improvement and prolonged survival. High gene-expression of angiotensinogen (AGT) is associated with a poor response to bevacizumab combination therapy. Because AGT gene-expression is epigenetically… read more here.
Keywords: methylation; bevacizumab; response; recurrent glioblastoma ... See more keywords
Improved Survival with Decreased Wait Time to Surgery in Glioblastoma Patients Presenting with Seizure
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DOI: 10.1093/neuros/nyx084
Abstract: BACKGROUND: Preoperative seizure is reported to confer favorable prognosis in glioblastoma patients, but studies to date have not investigated how broadly applicable seizure is as a prognostic factor. OBJECTIVE: To investigate if prompter surgical intervention… read more here.
Keywords: preoperative seizure; preoperative symptoms; glioblastoma; wait time ... See more keywords
Cytokine Microdialysis for Real-Time Immune Monitoring in Glioblastoma Patients Undergoing Checkpoint Blockade
Sign Up to like & getrecommendations! Published in 2019 at "Neurosurgery"
DOI: 10.1093/neuros/nyy392
Abstract: BACKGROUND Glioblastoma is the most common primary malignancy of the brain, with a dismal prognosis. Immunomodulation via checkpoint inhibition has provided encouraging results in non-CNS malignancies, but prediction of responders has proven to be challenging… read more here.
Keywords: microdialysis; checkpoint inhibition; checkpoint; brain ... See more keywords
The predictive value of partial MGMT promoter methylation for IDH-wild-type glioblastoma patients.
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DOI: 10.1093/nop/npac070
Abstract: Background Glioblastoma patients with hypermethylation of the O6-methylguanine-methyltransferase (MGMT) gene promoter have significantly improved survival when treated with temozolomide compared to patients with unmethylation of the MGMT promoter. However, the prognostic and predictive significance of… read more here.
Keywords: promoter; glioblastoma patients; methylation; mgmt promoter ... See more keywords
A Coclinical Radiogenomic Validation Study: Conserved Magnetic Resonance Radiomic Appearance of Periostin-Expressing Glioblastoma in Patients and Xenograft Models
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DOI: 10.1158/1078-0432.ccr-17-3420
Abstract: Purpose: Radiomics is the extraction of multidimensional imaging features, which when correlated with genomics, is termed radiogenomics. However, radiogenomic biological validation is not sufficiently described in the literature. We seek to establish causality between differential… read more here.
Keywords: postn expression; radiomic features; validation; expression status ... See more keywords
Impact of therapeutic modalities on disease-specific survival in older adults with glioblastoma: A single-institution retrospective cohort study
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Oncology Pharmacy Practice"
DOI: 10.1177/1078155219857792
Abstract: The standard first-line therapy for glioblastoma consists of maximal surgical resection, followed by concurrent chemoradiotherapy. Optimal management for older glioblastoma patients is unknown as they have not been extensively studied in clinical trials. We report… read more here.
Keywords: disease specific; glioblastoma; institution; oncology ... See more keywords