Targeting glioblastoma signaling and metabolism with a re-purposed brain-penetrant drug.
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DOI: 10.1016/j.celrep.2021.109957
Abstract: The highly lethal brain cancer glioblastoma (GBM) poses a daunting challenge because the blood-brain barrier renders potentially druggable amplified or mutated oncoproteins relatively inaccessible. Here, we identify sphingomyelin phosphodiesterase 1 (SMPD1), an enzyme that regulates… read more here.
Keywords: brain penetrant; targeting glioblastoma; drug; brain ... See more keywords