Epigenetic downregulation of TET3 reduces genome‐wide 5hmC levels and promotes glioblastoma tumorigenesis
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DOI: 10.1002/ijc.32520
Abstract: Loss of 5‐hydroxymethylcytosine (5hmC) has been associated with mutations of the ten–eleven translocation (TET) enzymes in several types of cancer. However, tumors with wild‐type TET genes can also display low 5hmC levels, suggesting that other… read more here.
Keywords: genome wide; 5hmc levels; epigenetic downregulation; glioblastoma tumorigenesis ... See more keywords
Messenger RNA Methylation Regulates Glioblastoma Tumorigenesis.
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DOI: 10.1016/j.ccell.2017.03.010
Abstract: Messenger RNA (mRNA) modification provides an additional layer of gene regulation in cells. In this issue of Cancer Cell, Zhang et al. report that ALKBH5, a demethylase of the mRNA modification N6-methyladenosine, regulates proliferation and self-renewal… read more here.
Keywords: rna methylation; glioblastoma tumorigenesis; messenger rna; messenger ... See more keywords