Signaling Determinants of Glioma Cell Invasion.
Sign Up to like & getrecommendations! Published in 2020 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-3-030-30651-9_7
Abstract: Tumor cell invasiveness is a critical challenge in the clinical management of glioma patients. In addition, there is accumulating evidence that current therapeutic modalities, including anti-angiogenic therapy and radiotherapy, can enhance glioma invasiveness. Glioma cell… read more here.
Keywords: signaling determinants; glioma; cell invasion; glioma cell ... See more keywords
Synergistic inhibition of glioma cell proliferation by Withaferin A and tumor treating fields
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Neuro-Oncology"
DOI: 10.1007/s11060-017-2534-5
Abstract: Glioblastoma (GBM) is the most aggressive and lethal form of brain cancer. Standard therapies are non-specific and often of limited effectiveness; thus, efforts are underway to uncover novel, unorthodox therapies against GBM. In previous studies,… read more here.
Keywords: proliferation; treating fields; glioma cell; cell ... See more keywords
AnnexinA5 promote glioma cell invasion and migration via the PI3K/Akt/NF-κB signaling pathway
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Neuro-Oncology"
DOI: 10.1007/s11060-018-2818-4
Abstract: As an important member of the Annexins, AnnexinA5 has been attributed important functions in trophoblast membrane repair, anticoagulation and cellular signal transduction. Accumulated studies show that AnnexinA5 is closely associated with various types of carcinomas.… read more here.
Keywords: akt signaling; glioma; pi3k akt; signaling pathway ... See more keywords
FERMT3 contributes to glioblastoma cell proliferation and chemoresistance to temozolomide through integrin mediated Wnt signaling
Sign Up to like & getrecommendations! Published in 2017 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2017.07.057
Abstract: FERMT3, also known as kindlin-3, is one of three kindlin family members expressed in mammals. Kindlins are cytosolic, adaptor proteins that are important activators and regulators of integrin function. They have also been shown to… read more here.
Keywords: chemoresistance; cell proliferation; proliferation chemoresistance; glioma cell ... See more keywords
MTSS1 is epigenetically regulated in glioma cells and inhibits glioma cell motility
Sign Up to like & getrecommendations! Published in 2017 at "Translational Oncology"
DOI: 10.1016/j.tranon.2016.11.006
Abstract: Epigenetic silencing by DNA methylation in brain tumors has been reported for many genes, however, their function on pathogenesis needs to be evaluated. We investigated the MTSS1 gene, identified as hypermethylated by differential methylation hybridization… read more here.
Keywords: glioma; cell motility; hypermethylation; mtss1 ... See more keywords
LncRNA-XIST interacts with miR-29c to modulate the chemoresistance of glioma cell to TMZ through DNA mismatch repair pathway
Sign Up to like & getrecommendations! Published in 2017 at "Bioscience Reports"
DOI: 10.1042/bsr20170696
Abstract: Temozolomide (TMZ) is the most commonly used alkylating agent in glioma chemotherapy. However, growing resistance to TMZ remains a major challenge for clinicians. Recent evidence emphasizes the key regulatory roles of non-coding RNAs (lncRNAs and… read more here.
Keywords: chemoresistance; glioma; tmz; glioma cell ... See more keywords
ApoC1 promotes glioma metastasis by enhancing epithelial-mesenchymal transition and activating the STAT3 pathway
Sign Up to like & getrecommendations! Published in 2022 at "Neurological Research"
DOI: 10.1080/01616412.2022.2132458
Abstract: ABSTRACT Objective: One of the apolipoprotein’s members, apolipoprotein C1 (ApoC1), is critical in the metabolism of both very-low-density lipoprotein (VLDL) and high-density lipoprotein (HDL) cholesterols. Multiple studies have recently revealed that ApoC1 may be a… read more here.
Keywords: mesenchymal transition; apoc1; glioma; epithelial mesenchymal ... See more keywords
miRNA-451 regulates the NF-κB signaling pathway by targeting IKKβ to inhibit glioma cell growth.
Sign Up to like & getrecommendations! Published in 2021 at "Cell cycle"
DOI: 10.1080/15384101.2021.1969496
Abstract: Glioblastoma multiforme (GBM) is associated with a poor prognosis, and effective treatments are lacking. Our previous studies have shown that miRNA-451 is closely related to the development and progression of glioma. miRNA-451 is a tumor… read more here.
Keywords: glioma; targeting ikk; signaling pathway; mirna 451 ... See more keywords
The ubiquitin hydrolase OTUB1 promotes glioma cell stemness via suppressing ferroptosis through stabilizing SLC7A11 protein
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DOI: 10.1080/21655979.2021.2011633
Abstract: ABSTRACT The ubiquitin hydrolase OTUB1 has been elucidated to be highly expressed in tumors, however, its roles in glioma progression are still confusing. Here, via analyzing several online datasets, OTUB1 expression was shown to be… read more here.
Keywords: slc7a11; glioma cell; cell stemness; expression ... See more keywords
Effect and mechanism of YB-1 knockdown on glioma cell growth, migration, and apoptosis.
Sign Up to like & getrecommendations! Published in 2020 at "Acta biochimica et biophysica Sinica"
DOI: 10.1093/abbs/gmz161
Abstract: Y-box binding protein 1 (YB-1) is manifested as its involvement in cell proliferation and differentiation and malignant cell transformation. Overexpression of YB-1 is associated with glioma progression and patient survival. The aim of this study… read more here.
Keywords: growth; knockdown glioma; glioma; apoptosis ... See more keywords
Small molecule-mediated disruption of ribosome biogenesis synergizes with FGFR inhibitors to suppress glioma cell growth
Sign Up to like & getrecommendations! Published in 2022 at "Neuro-Oncology"
DOI: 10.1093/neuonc/noac286
Abstract: Abstract Background High-grade gliomas are malignant brain tumors characterized by aggressiveness and resistance to chemotherapy. Prognosis remains dismal, highlighting the need to identify novel molecular dependencies and targets. Ribosome biogenesis (RiBi), taking place in the… read more here.
Keywords: growth; ribosome biogenesis; ribi; glioma ... See more keywords