PRRX1 induced by BMP signaling decreases tumorigenesis by epigenetically regulating glioma-initiating cell properties via DNA methyltransferase 3A.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular oncology"
DOI: 10.1002/1878-0261.13051
Abstract: Glioma-initiating cells (GICs), a major source of glioblastoma recurrence, are characterized by the expression of neural stem cell markers and the ability to grow by forming non-adherent spheres under serum-free conditions. Bone morphogenetic proteins (BMPs),… read more here.
Keywords: prrx1 induced; cell; glioma initiating; dna methyltransferase ... See more keywords
Targeting CXCR4 to suppress glioma‐initiating cells and chemoresistance in glioma
Sign Up to like & getrecommendations! Published in 2022 at "Cell Biology International"
DOI: 10.1002/cbin.11836
Abstract: Glioma initiating cells (GICs), also known as glioma stem cells, display the capacity to recapitulate the functional diversity within the tumor. Despite the great progress achieved over the last decades, defining the key molecular regulators… read more here.
Keywords: cxcr4; klf5; glioma initiating; glioma ... See more keywords
Chromatin Remodeling Factor BRG1 Regulates Stemness and Chemosensitivity of Glioma Initiating Cells
Sign Up to like & getrecommendations! Published in 2018 at "STEM CELLS"
DOI: 10.1002/stem.2909
Abstract: Glioblastoma multiforme (GBM) is a highly aggressive and malignant brain tumor that is refractory to existing therapeutic regimens, which reflects the presence of stem‐like cells, termed glioma‐initiating cells (GICs). The complex interactions between different signaling… read more here.
Keywords: brg1; chromatin remodeling; stemness chemosensitivity; initiating cells ... See more keywords
Targeting Glioma Initiating Cells with A combined therapy of cannabinoids and temozolomide
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical Pharmacology"
DOI: 10.1016/j.bcp.2018.09.007
Abstract: Graphical abstract Figure. No Caption available. ABSTRACT Glioblastoma multiforme (GBM) is the most frequent and aggressive type of brain tumor due, at least in part, to its poor response to current anticancer treatments. These features… read more here.
Keywords: cbd; initiating cells; glioma initiating; tmz ... See more keywords
Therapeutic potential of pentamidine for glioma-initiating cells and glioma cells through multimodal antitumor effects.
Sign Up to like & getrecommendations! Published in 2023 at "Cancer science"
DOI: 10.1111/cas.15827
Abstract: Glioma-initiating cells, which comprise a heterogeneous population of glioblastomas, contribute to resistance against aggressive chemoradiotherapy. Using drug reposition, we investigated a therapeutic drug for glioma-initiating cells. Drug screening was undertaken to select candidate agents that… read more here.
Keywords: pentamidine; glioma initiating; glioma; initiating cells ... See more keywords
Cyclophilin A Maintains Glioma-Initiating Cell Stemness by Regulating Wnt/β-Catenin Signaling
Sign Up to like & getrecommendations! Published in 2017 at "Clinical Cancer Research"
DOI: 10.1158/1078-0432.ccr-17-0774
Abstract: Purpose: Glioma-initiating cells (GIC) are glioma stem–like cells that contribute to glioblastoma (GBM) development, recurrence, and resistance to chemotherapy and radiotherapy. They have recently become the focus of novel treatment strategies. Cyclophilin A (CypA) is… read more here.
Keywords: stemness; gic stemness; catenin signaling; catenin ... See more keywords
Targeting glioma-initiating cells via the tyrosine metabolic pathway.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of neurosurgery"
DOI: 10.3171/2019.11.jns192028
Abstract: OBJECTIVE Despite an aggressive multimodal therapeutic regimen, glioblastoma (GBM) continues to portend a grave prognosis, which is driven in part by tumor heterogeneity at both the molecular and cellular levels. Accordingly, herein the authors sought… read more here.
Keywords: tyrosine metabolic; metabolic pathway; core; glioma initiating ... See more keywords
Genetic and Lineage Classification of Glioma-Initiating Cells Identifies a Clinically Relevant Glioblastoma Model
Sign Up to like & getrecommendations! Published in 2019 at "Cancers"
DOI: 10.3390/cancers11101564
Abstract: The Cancer Genome Atlas (TCGA) project described a robust gene expression-based molecular classification of glioblastoma (GBM), but the functional and biological significance of the subclasses has not been determined. The present comprehensive analysis of 25… read more here.
Keywords: genetic lineage; classification; glioma initiating; glioblastoma ... See more keywords