Investigating the Interactions of Glioma Stem Cells in the Perivascular Niche at Single‐Cell Resolution using a Microfluidic Tumor Microenvironment Model
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Science"
DOI: 10.1002/advs.202201436
Abstract: The perivascular niche (PVN) is a glioblastoma tumor microenvironment (TME) that serves as a safe haven for glioma stem cells (GSCs), and acts as a reservoir that inevitably leads to tumor recurrence. Understanding cellular interactions… read more here.
Keywords: cell; glioma stem; tumor microenvironment; perivascular niche ... See more keywords
Detailed longitudinal sampling of glioma stem cells in situ reveals Chr7 gain and Chr10 loss as repeated events in primary tumor formation and recurrence
Sign Up to like & getrecommendations! Published in 2017 at "International Journal of Cancer"
DOI: 10.1002/ijc.30887
Abstract: Intratumoral heterogeneity at the genetic, epigenetic, transcriptomic, and morphologic levels is a commonly observed phenomenon in many aggressive cancer types. Clonal evolution during tumor formation and in response to therapeutic intervention can be predicted utilizing… read more here.
Keywords: tumor; glioma stem; gain; tumor formation ... See more keywords
RETRACTED ARTICLE: Astrocytes Regulate Differentiation and Glutamate Uptake of Glioma Stem Cells via Formyl Peptide Receptor
Sign Up to like & getrecommendations! Published in 2020 at "Cellular and Molecular Neurobiology"
DOI: 10.1007/s10571-020-00886-3
Abstract: The role of astrocytes on glutamate release and differentiation of glioma stem cells (GSCs) remains unknown. We investigated glutamate release, proliferation, and differentiation of GSCs after indirect incubation with astrocytes in vitro, including morphology change,… read more here.
Keywords: stem cells; glioma stem; glutamate uptake; differentiation ... See more keywords
Convection-enhanced delivery of sulfasalazine prolongs survival in a glioma stem cell brain tumor model
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Neuro-Oncology"
DOI: 10.1007/s11060-017-2621-7
Abstract: Expression of CD44 in glioma cells was previously correlated with tumor grade and is considered a stem cell marker. CD44 stabilizes the cystine–glutamate transporter (xCT) and inhibits apoptosis in cancer stem cells (CSCs). Recently it… read more here.
Keywords: glioma stem; stem cell; ssz; stem ... See more keywords
Apigenin increases radiosensitivity of glioma stem cells by attenuating HIF-1α-mediated glycolysis
Sign Up to like & getrecommendations! Published in 2021 at "Medical Oncology"
DOI: 10.1007/s12032-021-01586-8
Abstract: Apigenin, a natural flavonoid compound present in a variety of edible plants and health foods, has an anti-tumor effect and inhibits hypoxia inducible factor-lα (HIF-1α) expression in hypertrophic cardiac tissues. However, whether or not apigenin… read more here.
Keywords: hif; glioma stem; apigenin; expression ... See more keywords
Radiotherapy and Glioma Stem Cells: Searching for Chinks in Cellular Armor
Sign Up to like & getrecommendations! Published in 2017 at "Current Stem Cell Reports"
DOI: 10.1007/s40778-017-0102-8
Abstract: Purpose of ReviewRadiation became a pillar of oncologic treatment in the last century and provided a powerful and effective locoregional treatment of solid malignancies. After achieving some of the first cures in lymphomas and skin… read more here.
Keywords: glioma stem; radiotherapy glioma; stem; stem cells ... See more keywords
RGFP966, a Histone deacetylase 3 inhibitor, promotes glioma stem cell differentiation by blocking TGF-β signaling via SMAD7.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical pharmacology"
DOI: 10.1016/j.bcp.2020.114118
Abstract: Glioma stem cells (GSC) play a major role in drug resistance and tumor recurrence. Using a genetic screen with a set of shRNAs that can target chromatin regulators in a GSC model, we have HDAC3… read more here.
Keywords: inhibitor; glioma stem; differentiation; tgf signaling ... See more keywords
Long non-coding RNA RP5-821D11.7 promotes proliferation, migration, and epithelial-mesenchymal transition in glioma and glioma stem-like cells.
Sign Up to like & getrecommendations! Published in 2021 at "Progress in biophysics and molecular biology"
DOI: 10.1016/j.pbiomolbio.2021.12.001
Abstract: Long noncoding RNA (lncRNA) has been recently revealed as a main regulatory molecule, which implicates many cellular functions. Studies showed that lncRNA abnormally expressed and involved in the progression and tumorigenesis of glioma. Present study… read more here.
Keywords: stem like; glioma stem; lncrna rp5; rp5 ... See more keywords
Reconstituting Glioma Perivascular Niches on a Chip for Insights into Chemoresistance of Glioma.
Sign Up to like & getrecommendations! Published in 2018 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.8b02133
Abstract: In this work, we report the direct diagnosing chemoresistance of glioma stem cells (GSCs) during chemotherapy on a biomimetric microsystem that reconstitutes glioma perivascular niches on a chip. Glioma stem cells and endothelial cells were… read more here.
Keywords: glioma stem; chemoresistance; glioma; perivascular niches ... See more keywords
Nanomedicines Targeting Glioma Stem Cells.
Sign Up to like & getrecommendations! Published in 2022 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.2c03538
Abstract: Glioblastoma (GBM), classified as a grade IV glioma, is a rapidly growing, aggressive, and most commonly occurring tumor of the central nervous system. Despite the therapeutic advances, it carries an ominous prognosis, with a median… read more here.
Keywords: glioma stem; targeting glioma; nanomedicines targeting; stem ... See more keywords
Targeting Glioma Stem Cells through Combined BMI1 and EZH2 Inhibition
Sign Up to like & getrecommendations! Published in 2017 at "Nature medicine"
DOI: 10.1038/nm.4415
Abstract: Glioblastomas are lethal cancers defined by angiogenesis and pseudopalisading necrosis. Here, we demonstrate that these histological features are associated with distinct transcriptional programs, with vascular regions showing a proneural profile, and hypoxic regions showing a… read more here.
Keywords: stem cells; inhibition; glioma stem; mesenchymal gscs ... See more keywords