Globularifolin exerts anticancer effects on glioma U87 cells through inhibition of Akt/mTOR and MEK/ERK signaling pathways in vitro and inhibits tumor growth in vivo.
Sign Up to like & getrecommendations! Published in 2017 at "Biochimie"
DOI: 10.1016/j.biochi.2017.09.005
Abstract: Gliomas are the most recurrently occurring primary malignancies in the central nervous system. Despite surgical interventions, chemo- and radiotherapy, the results are unfortunately poor. Therefore, there is pressing need to explore more effective and efficient… read more here.
Keywords: u87 cells; inhibition akt; globularifolin; glioma ... See more keywords
Design, synthesis, DNA binding studies and evaluation of anticancer potential of novel substituted biscarbazole derivatives against human glioma U87 MG cell line.
Sign Up to like & getrecommendations! Published in 2020 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2020.103911
Abstract: In this research paper, we report the design and synthesis of novel substituted biscarbazole derivatives which were characterized by 1H and 13C NMR, high resolution mass spectroscopy (HRMS). The SAR study of the compounds is… read more here.
Keywords: novel; cell line; human glioma; biscarbazole derivatives ... See more keywords
Antitumor activity of tetrandrine citrate in human glioma U87 cells in vitro and in vivo
Sign Up to like & getrecommendations! Published in 2019 at "Oncology Reports"
DOI: 10.3892/or.2019.7372
Abstract: Since the current methods of treatment for malignant glioma, radiotherapy and chemotherapy, are unsatisfactory, the development of novel therapeutic compounds is required. In the present study, the inhibitory effect of tetrandrine citrate (TetC) on the… read more here.
Keywords: u87 cells; human glioma; glioma; glioma u87 ... See more keywords