Association of MGMT Promotor Methylation With Survival in Low-grade and Anaplastic Gliomas After Alkylating Chemotherapy.
Sign Up to like & getrecommendations! Published in 2023 at "JAMA oncology"
DOI: 10.1001/jamaoncol.2023.0990
Abstract: Importance O6-methylguanine-DNA methyltransferase (MGMT [OMIM 156569]) promoter methylation (mMGMT) is predictive of response to alkylating chemotherapy for glioblastomas and is routinely used to guide treatment decisions. However, the utility of MGMT promoter status for low-grade… read more here.
Keywords: gliomas; idh; alkylating chemotherapy; ahr ... See more keywords
Targeting mitochondrial energetics reverses panobinostat- and marizomib-induced resistance in pediatric and adult high-grade gliomas.
Sign Up to like & getrecommendations! Published in 2023 at "Molecular oncology"
DOI: 10.1002/1878-0261.13427
Abstract: In previous studies, we demonstrated that panobinostat, a histone deacetylase inhibitor, and the proteasomal inhibitor bortezomib displayed synergistic therapeutic activity against pediatric and adult high-grade gliomas. Despite the remarkable initial response to this combination, resistance… read more here.
Keywords: adult high; pediatric adult; panobinostat marizomib; gliomas ... See more keywords
Modulating Nanozyme‐Based Nanomachines via Microenvironmental Feedback for Differential Photothermal Therapy of Orthotopic Gliomas
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Science"
DOI: 10.1002/advs.202204937
Abstract: Gliomas are common and refractory primary tumors closely associated with the fine structures of the brain. Photothermal therapy (PTT) has recently shown promise as an effective treatment for gliomas. However, nonspecific accumulation of photothermal agents… read more here.
Keywords: photothermal therapy; brain; gliomas; orthotopic gliomas ... See more keywords
Radiomic study on preoperative multi‐modal magnetic resonance images identifies IDH‐mutant TERT promoter‐mutant gliomas
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Medicine"
DOI: 10.1002/cam4.5097
Abstract: Gliomas with comutations of isocitrate dehydrogenase (IDH) genes and telomerase reverse transcriptase (TERT) gene promoter (IDHmut pTERTmut) show distinct biological features and respond to first‐line treatment differently in comparison with other gliomas. This study aimed… read more here.
Keywords: promoter; study preoperative; gliomas; preoperative multi ... See more keywords
Identification of thioredoxin domain containing family members' expression pattern and prognostic value in diffuse gliomas via in silico analysis
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Medicine"
DOI: 10.1002/cam4.5169
Abstract: Gliomas are the most prevalent primary tumors of the central nervous system. Their aggressive nature and the obstacles arising during therapy highlights the importance of finding new prognostic markers and therapy targets for gliomas. TXNDC… read more here.
Keywords: family members; gliomas; identification thioredoxin; diffuse gliomas ... See more keywords
Probing the phosphatidylinositol 3‐kinase/mammalian target of rapamycin pathway in gliomas: A phase 2 study of everolimus for recurrent adult low‐grade gliomas
Sign Up to like & getrecommendations! Published in 2017 at "Cancer"
DOI: 10.1002/cncr.30909
Abstract: Activation of the phosphatidylinositol 3‐kinase (PI3K)/mammalian target of rapamycin (mTOR) pathway is common in patients with low‐grade gliomas (LGGs), but agents that inhibit this pathway, including mTOR inhibitors, have not been studied in this population. read more here.
Keywords: gliomas; mammalian target; phosphatidylinositol kinase; target rapamycin ... See more keywords
Noninvasive detection of brain gliomas using plasma cell‐free DNA 5‐hydroxymethylcytosine sequencing
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Cancer"
DOI: 10.1002/ijc.34401
Abstract: Liquid biopsy techniques based on deep sequencing of plasma cell‐free DNA (cfDNA) could detect the low‐frequency somatic mutations and provide an accurate diagnosis for many cancers. However, for brain gliomas, reliable performance of these techniques… read more here.
Keywords: brain gliomas; cell free; plasma cell; gliomas ... See more keywords
FFCAEs: An efficient feature fusion framework using cascaded autoencoders for the identification of gliomas
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Imaging Systems and Technology"
DOI: 10.1002/ima.22820
Abstract: Intracranial tumors arise from constituents of the brain and its meninges. Glioblastoma (GBM) is the most common adult primary intracranial neoplasm and is categorized as high‐grade astrocytoma according to the World Health Organization (WHO). The… read more here.
Keywords: ffcaes efficient; fusion; feature fusion; cascaded autoencoders ... See more keywords
Efficacy of three-dimensional arterial spin labeling and how it compares against that of contrast enhanced magnetic resonance imaging in preoperative grading of brain gliomas.
Sign Up to like & getrecommendations! Published in 2023 at "Environmental toxicology"
DOI: 10.1002/tox.23800
Abstract: PURPOSE To evaluate the efficacy of three-dimensional arterial spin labeling (3D-ASL) imaging in preoperative grading of brain gliomas, and compare the discrepancy between images obtained from 3D-ASL and contrast enhanced magnetic resonance imaging (CE-MRI) in… read more here.
Keywords: rtbf; brain gliomas; preoperative grading; gliomas ... See more keywords
Amide proton transfer-weighted MRI in distinguishing high- and low-grade gliomas: a systematic review and meta-analysis
Sign Up to like & getrecommendations! Published in 2018 at "Neuroradiology"
DOI: 10.1007/s00234-018-02152-2
Abstract: PurposeGrading of brain gliomas is of clinical importance, and noninvasive molecular imaging may help differentiate low- and high-grade gliomas. We aimed to evaluate the diagnostic performance of amide proton transfer-weighted (APTw) MRI for differentiating low-… read more here.
Keywords: gliomas; aptw mri; high grade; grade ... See more keywords
The diagnostic role of diffusional kurtosis imaging in glioma grading and differentiation of gliomas from other intra-axial brain tumours: a systematic review with critical appraisal and meta-analysis
Sign Up to like & getrecommendations! Published in 2020 at "Neuroradiology"
DOI: 10.1007/s00234-020-02425-9
Abstract: Purpose We aim to illustrate the diagnostic performance of diffusional kurtosis imaging (DKI) in the diagnosis of gliomas. Methods A review protocol was developed according to the (PRISMA-P) checklist, registered in the international prospective register… read more here.
Keywords: gliomas; diffusional kurtosis; kurtosis; differentiation ... See more keywords