NIMG-10. THE ROLE OF FIBROBLAST ACTIVATION PROTEIN IN GLIOBLASTOMA AND GLIOSARCOMA – A COMPARISON OF TISSUE, 68GA-FAPI-46 POSITRON EMISSION TOMOGRAPHY AND SURVIVAL DATA
Sign Up to like & getrecommendations! Published in 2024 at "Neuro-Oncology"
DOI: 10.1093/neuonc/noae165.0776
Abstract: Despite their unique histological features,gliosarcomas belong to the group of glioblastomas and are treated according to the same standards. Fibroblast-activation-protein(FAP) is a component of a tumor-specific subpopulation of fibroblasts that play a critical role in… read more here.
Keywords: fap expression; gliosarcoma; tumor; expression ... See more keywords
Molecular and clonal evolution in recurrent metastatic gliosarcoma
Sign Up to like & getrecommendations! Published in 2020 at "Cold Spring Harbor Molecular Case Studies"
DOI: 10.1101/mcs.a004671
Abstract: We discuss the molecular evolution of gliosarcoma, a mesenchymal type of glioblastoma (GBM), using the case of a 37-yr-old woman who developed two recurrences and an extracranial metastasis. She was initially diagnosed with isocitrate dehydrogenase… read more here.
Keywords: evolution; treated surgery; metastasis; gliosarcoma ... See more keywords
Molecular Characteristics of a ZFTA::RELA Fusion Gliosarcoma: A Case Report
Sign Up to like & getrecommendations! Published in 2025 at "International Journal of Surgical Pathology"
DOI: 10.1177/10668969241311520
Abstract: The combination of ependymoma and gliosarcoma elements in the same tumor is extremely rare, and the molecular characteristics of these entities are not clear. Here, we present a rare aggressive brain tumor in a 12-year-old… read more here.
Keywords: report; zfta rela; fusion; characteristics zfta ... See more keywords
Secondary gliosarcoma: the clinicopathological features and the development of a patient-derived xenograft model of gliosarcoma
Sign Up to like & getrecommendations! Published in 2021 at "BMC Cancer"
DOI: 10.1186/s12885-021-08008-y
Abstract: Background Gliosarcoma (GSM) is a distinct and aggressive variant of glioblastoma multiforme (GBM) with worse prognosis and few treatment options. It is often managed with the same treatment modalities with temozolomide (TMZ) as in GBM.… read more here.
Keywords: gsm; derived xenograft; model; gliosarcoma ... See more keywords
An IDH1-mutated primary gliosarcoma: case report.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of neurosurgery"
DOI: 10.3171/2016.2.jns151482
Abstract: The authors present the case of a primary gliosarcoma with an isocitrate dehydrogenase-1 (IDH1) mutation. A 75-year-old man presented with a 3-day history of multiple focal seizures and was found on MRI to have a… read more here.
Keywords: isocitrate dehydrogenase; case; primary gliosarcoma; idh1 ... See more keywords
Can a signature molecular-profile define disparate survival in BRAF-positive Gliosarcoma and identify novel targets for therapeutic intervention?
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cancer Research and Therapeutics"
DOI: 10.4103/jcrt.jcrt_1900_20
Abstract: Purpose: Gliosarcoma (GS) has a low incidence but is aggressively invasive, with poor-survival. Even though GS is recognized as a different subgroup from glioblastoma (GB), there is no molecular panel available to define its clinical… read more here.
Keywords: htert hmga; define; survival; braf ... See more keywords