Microglial‐induced Müller cell gliosis is attenuated by progesterone in a mouse model of retinitis pigmentosa
Sign Up to like & getrecommendations! Published in 2018 at "Glia"
DOI: 10.1002/glia.23243
Abstract: Norgestrel, a progesterone analogue, has demonstrated neuroprotective effects in a mouse model of retinitis pigmentosa. Neuroprotection is achieved in part through Norgestrels anti‐inflammatory properties, alleviating detrimental microglial activity. Gliosis is a feature of many neurodegenerative… read more here.
Keywords: ller; gliosis; retinitis pigmentosa; cell gliosis ... See more keywords
Müller Glia Reactivity and Development of Gliosis in Response to Pathological Conditions.
Sign Up to like & getrecommendations! Published in 2018 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-3-319-75402-4_37
Abstract: Within the mammalian retina, both Müller glia and astrocytes display reactivity in response to many forms of retinal injury and disease in a process termed gliosis. Reactive gliosis is a complex process that is considered… read more here.
Keywords: response; ller glia; pathological conditions; gliosis ... See more keywords
Glia maturation factor beta is required for reactive gliosis after traumatic brain injury in zebrafish
Sign Up to like & getrecommendations! Published in 2018 at "Experimental Neurology"
DOI: 10.1016/j.expneurol.2018.04.008
Abstract: ABSTRACT Gliosis is a hallmark of neural pathology that occurs after most forms of central nervous system (CNS) injuries including traumatic brain injury (TBI). Identification of genes that control gliosis may provide novel treatment targets… read more here.
Keywords: gmfb mutant; reactive gliosis; gliosis; tbi ... See more keywords
Stroke subtype-dependent synapse elimination by reactive gliosis in mice.
Sign Up to like & getrecommendations! Published in 2021 at "Nature communications"
DOI: 10.1038/s41467-021-27248-x
Abstract: The pathological role of reactive gliosis in CNS repair remains controversial. In this study, using murine ischemic and hemorrhagic stroke models, we demonstrated that microglia/macrophages and astrocytes are differentially involved in engulfing synapses in the… read more here.
Keywords: synapse; reactive gliosis; stroke subtype; gliosis ... See more keywords
Evaluating the in vivo glial response to miniaturized parylene cortical probes coated with an ultra-fast degrading polymer to aid insertion.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of neural engineering"
DOI: 10.1088/1741-2552/aa9fad
Abstract: OBJECTIVE Despite the feasibility of short-term neural recordings using implantable microelectrodes, attaining reliable, chronic recordings remains a challenge. Most neural recording devices suffer from a long-term tissue response, including gliosis, at the device-tissue interface. It… read more here.
Keywords: glial response; response; gliosis; polymer ... See more keywords
TERT Promoter Mutation Analysis to Distinguish Glioma From Gliosis.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of neuropathology and experimental neurology"
DOI: 10.1093/jnen/nlaa004
Abstract: Among the most challenging diagnostic issues in surgical neuropathology is the distinction between scant infiltration by diffuse gliomas and reactive gliosis. The best documented ancillary marker to establish a definitive diagnosis of glioma in this… read more here.
Keywords: gliomas; analysis; tert promoter; gliosis ... See more keywords
EXCESSIVE GLIOSIS AFTER VITRECTOMY FOR THE HIGHLY MYOPIC MACULAR HOLE
Sign Up to like & getrecommendations! Published in 2023 at "Retina"
DOI: 10.1097/iae.0000000000003657
Abstract: Supplemental Digital Content is Available in the Text. Our study indicated that while the inverted internal limiting membrane flap surgery was beneficial in treating refractory macular holes, it was associated with excessive gliosis in highly… read more here.
Keywords: highly myopic; internal limiting; gliosis; macular hole ... See more keywords
Pathological Study of Untreated Intraretinal Gliosis Surgically Excised via Pars Plana Vitrectomy.
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DOI: 10.1097/iae.0000000000003777
Abstract: PURPOSE To evaluate the pathological process of intraretinal glioses by investigating mass tissues resected from untreated eyes with intraretinal glioses. METHODS Five patients with intraretinal gliosis without previous conservative treatment were included. All patients underwent… read more here.
Keywords: plana vitrectomy; intraretinal glioses; pathological study; gliosis ... See more keywords
Toxicologic Pathology Forum Opinion: Interpretation of Gliosis in the Brain and Spinal Cord Observed During Nonclinical Safety Studies.
Sign Up to like & getrecommendations! Published in 2023 at "Toxicologic pathology"
DOI: 10.1177/01926233231164557
Abstract: Gliosis, defined as a nonneoplastic reaction (hypertrophy and/or proliferation) of astrocytes and/or microglial cells, is a frequent finding in the central nervous system (CNS [brain and/or spinal cord]) in nonclinical safety studies. Gliosis in rodents… read more here.
Keywords: brain spinal; nonclinical safety; safety studies; pathology ... See more keywords
High-fat diet increases gliosis and immediate early gene expression in APOE3 mice, but not APOE4 mice
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Neuroinflammation"
DOI: 10.1186/s12974-021-02256-2
Abstract: Background APOE 4 is the strongest genetic risk factor for Alzheimer’s disease (AD), and obesity is a strong environmental risk factor for AD. These factors result in multiple central nervous system (CNS) disturbances and significantly… read more here.
Keywords: hfd; apoe; gliosis; high fat ... See more keywords
A novel P2X2‐dependent purinergic mechanism of enteric gliosis in intestinal inflammation
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DOI: 10.15252/emmm.202012724
Abstract: Enteric glial cells (EGC) modulate motility, maintain gut homeostasis, and contribute to neuroinflammation in intestinal diseases and motility disorders. Damage induces a reactive glial phenotype known as “gliosis”, but the molecular identity of the inducing… read more here.
Keywords: novel p2x2; p2x2 dependent; inflammation; gliosis ... See more keywords