Gliotoxin Analogues from Endophytic Penicillium sp. of Eucommia ulmoides and Their Antimicrobial Activity
Sign Up to like & getrecommendations! Published in 2019 at "Chemistry of Natural Compounds"
DOI: 10.1007/s10600-019-02815-3
Abstract: Gliotoxin, displaying this typical bridged disulfide, was described in 1943 [1]. It is one of the better known members of the epipo-lythiodioxopiperazine (ETP) class of fungal metabolites. The structure of the ETP class of fungal… read more here.
Keywords: gliotoxin; eucommia ulmoides; ethyl acetate; silica gel ... See more keywords
Histopathological changes and expression of transforming growth factor beta (TGF-β3) in mice exposed to gliotoxin
Sign Up to like & getrecommendations! Published in 2020 at "Journal of King Saud University - Science"
DOI: 10.1016/j.jksus.2018.10.013
Abstract: Abstract Background Gliotoxin (GT) is the prototype of a class of epipolythiodioxopiperazines (ETPs) which are secondary metabolites made by fungi organisms only e.g., Aspergillus fumigatus, characterized by a disulfide bridge across a piperazine ring with… read more here.
Keywords: changes expression; mice; transforming growth; expression transforming ... See more keywords
Development of a Fluorescently Labeled Aptamer Structure-Switching Assay for Sensitive and Rapid Detection of Gliotoxin.
Sign Up to like & getrecommendations! Published in 2019 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.8b05094
Abstract: Gliotoxin, one of the most toxic metabolites produced during the growth of Aspergillus fumigatus, can cause direct damage to the immune system and results in infection and spread of Aspergillus, or even leads to invasive… read more here.
Keywords: gliotoxin; detection; aptamer structure; detection gliotoxin ... See more keywords
Gliotoxin and related metabolites as zinc chelators: implications and exploitation to overcome antimicrobial resistance.
Sign Up to like & getrecommendations! Published in 2023 at "Essays in biochemistry"
DOI: 10.1042/ebc20220222
Abstract: Antimicrobial resistance (AMR) is a major global problem and threat to humanity. The search for new antibiotics is directed towards targeting of novel microbial systems and enzymes, as well as augmenting the activity of pre-existing… read more here.
Keywords: gliotoxin; activity; gliotoxin related; antimicrobial resistance ... See more keywords
Dynamics of gliotoxin and bis(methylthio)gliotoxin production during the course of Aspergillus fumigatus infection.
Sign Up to like & getrecommendations! Published in 2022 at "Medical mycology"
DOI: 10.1093/mmy/myac025
Abstract: As recently described, fungal secondary metabolism activates during infection in response to a hostile host environment. Gliotoxin and bis(methylthio)gliotoxin are two recognized secondary metabolites produced by Aspergillus fumigatus with differential cytotoxicity and involved in virulence.… read more here.
Keywords: gliotoxin; infection; bis methylthio; gliotoxin bis ... See more keywords
Exposure to the Pseudomonas aeruginosa secretome alters the proteome and secondary metabolite production of Aspergillus fumigatus
Sign Up to like & getrecommendations! Published in 2022 at "Microbiology"
DOI: 10.1099/mic.0.001164
Abstract: The fungal pathogen Aspergillus fumigatus is frequently cultured from the sputum of cystic fibrosis (CF) patients along with the bacterium Pseudomonas aeruginosa. A. fumigatus secretes a range of secondary metabolites, and one of these, gliotoxin,… read more here.
Keywords: pseudomonas aeruginosa; aspergillus fumigatus; gliotoxin; fumigatus ... See more keywords
DETECTION OF GLIOTOXIN BUT NOT BIS(METHYL)GLIOTOXIN IN PLASMA FROM BIRDS WITH CONFIRMED AND PROBABLE ASPERGILLOSIS
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Zoo and Wildlife Medicine"
DOI: 10.1638/2021-0070
Abstract: Abstract: Aspergillosis remains a difficult disease to diagnose antemortem in many species, especially avian species. In the present study, banked plasma samples from various avian species were examined for gliotoxin (GT), which is a recognized… read more here.
Keywords: bis methyl; gliotoxin; aspergillosis; methyl gliotoxin ... See more keywords
Gliotoxin Targets Nuclear NOTCH2 in Human Solid Tumor Derived Cell Lines In Vitro and Inhibits Melanoma Growth in Xenograft Mouse Model
Sign Up to like & getrecommendations! Published in 2017 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2017.00319
Abstract: Deregulation of NOTCH2 signaling is implicated in a wide variety of human neoplasias. The current concept of targeting NOTCH is based on using gamma secretase inhibitors (GSI) to regulate the release of the active NOTCH… read more here.
Keywords: gliotoxin; human solid; cell lines; solid tumor ... See more keywords
Novel Action Targets of Natural Product Gliotoxin in Photosynthetic Apparatus
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Plant Science"
DOI: 10.3389/fpls.2019.01688
Abstract: Gliotoxin (GT) is a fungal secondary metabolite that has attracted great interest due to its high biological activity since it was discovered by the 1930s. It exhibits a unique structure that contains a N-C =… read more here.
Keywords: psii; gliotoxin; targets natural; novel action ... See more keywords