Mechanism-based selection of stabilization strategy for amorphous formulations: Insights into crystallization pathways
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Controlled Release"
DOI: 10.1016/j.jconrel.2017.04.015
Abstract: Abstract We developed a step‐by‐step experimental protocol using differential scanning calorimetry (DSC), dynamic vapour sorption (DVS), polarized light microscopy (PLM) and a small‐scale dissolution apparatus (&mgr;DISS Profiler) to investigate the mechanism (solid‐to‐solid or solution‐mediated) by… read more here.
Keywords: mechanism; crystallization; glipizide; indapamide metolazone ... See more keywords
OATP1B3 (699G>A) and CYP2C9*2, *3 significantly influenced the transport and metabolism of glibenclamide and glipizide
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-36212-7
Abstract: Glibenclamide and glipizide show large substantial inter-individual variation in clinical efficacy, which may be resulted from the genetic differences of metabolic enzymes and transporters in individuals. This study purposed to investigate the effect of OATP1B3… read more here.
Keywords: metabolism glibenclamide; glipizide; transport metabolism; oatp1b3 699g ... See more keywords
Theoretical insights into the radical scavenging activity of glipizide: DFT and molecular docking studies
Sign Up to like & getrecommendations! Published in 2022 at "Free Radical Research"
DOI: 10.1080/10715762.2022.2034803
Abstract: Abstract Glipizide is an N-sulfonylurea compound used in the treatment of hyperglycemia in patients with type 2 diabetes mellitus. In the present study, DFT-based computational methods and molecular docking studies have been performed to systematically… read more here.
Keywords: molecular docking; transfer; dft; glipizide ... See more keywords
The presence of two reduced function variants in CYP2C9 influences the acute response to glipizide
Sign Up to like & getrecommendations! Published in 2019 at "Diabetic Medicine"
DOI: 10.1111/dme.14176
Abstract: To examine whether the presence of two common missense variants in the CYP2C9 gene (rs1799853, encoding Arg144Cys and denoted as *2, and rs1057910, encoding Ile359Leu and denoted as *3) influences the acute physiological response to… read more here.
Keywords: response; influences acute; variants cyp2c9; presence two ... See more keywords
Formulation, Characterization, and Pharmacokinetic Evaluation of Novel Glipizide-Phospholipid Nano-complexes with Improved Solubility and Bioavailability.
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceutical nanotechnology"
DOI: 10.2174/2211738510666220328151512
Abstract: BACKGROUND The proposed study was aimed to formulate and evaluate the Glipizide-Phospholipid Nano-complex. Since Glipizide is a poorly soluble drug, its complexation with phospholipids is an ideal approach to improving solubility. METHOD To improve the… read more here.
Keywords: glipizide phospholipid; phospholipid nano; solubility; glipizide ... See more keywords