PIAS-family proteins negatively regulate Glis3 transactivation function through SUMO modification in pancreatic β cells
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DOI: 10.1016/j.heliyon.2018.e00709
Abstract: Gli-similar 3 (Glis3) is Krüppel-like transcription factor associated with the transcriptional regulation of insulin. Mutations within the Glis3 locus have been implicated in a number of pathologies including diabetes mellitus and hypothyroidism. Despite its clinical… read more here.
Keywords: function sumo; glis3 transactivation; pias family; transactivation function ... See more keywords