Methylglyoxal-derived advanced glycation end products contribute to negative cardiac remodeling and dysfunction post-myocardial infarction
Sign Up to like & getrecommendations! Published in 2017 at "Basic Research in Cardiology"
DOI: 10.1007/s00395-017-0646-x
Abstract: Advanced glycation end-products (AGEs) have been associated with poorer outcomes after myocardial infarction (MI), and linked with heart failure. Methylglyoxal (MG) is considered the most important AGE precursor, but its role in MI is unknown.… read more here.
Keywords: glo1; end products; glycation end; post ... See more keywords
GLO1 gene polymorphisms and their association with retinitis pigmentosa: a case–control study in a Sicilian population
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Biology Reports"
DOI: 10.1007/s11033-018-4295-4
Abstract: Glyoxalase 1 (GLO1) is a ubiquitous cellular enzyme involved in detoxification of methylglyoxal (MGO), a cytotoxic byproduct of glycolysis, whose excess can cause oxidative stress. In retinitis pigmentosa (RP), the prevalent cause of blindness just… read more here.
Keywords: glo1; sicilian population; retinitis pigmentosa;
Compensatory mechanisms for methylglyoxal detoxification in experimental & clinical diabetes
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Metabolism"
DOI: 10.1016/j.molmet.2018.09.005
Abstract: Objectives The deficit of Glyoxalase I (Glo1) and the subsequent increase in methylglyoxal (MG) has been reported to be one the five mechanisms by which hyperglycemia causes diabetic late complications. Aldo-keto reductases (AKR) have been… read more here.
Keywords: detoxification experimental; detoxification; glo1; methylglyoxal detoxification ... See more keywords
Imaging Tumorous Methylglyoxal by an Activatable Near-Infrared Fluorescent Probe for Monitoring Glyoxalase 1 Activity.
Sign Up to like & getrecommendations! Published in 2019 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.9b03600
Abstract: The accurate detection of tumorous methylglyoxal (MGO) and its detoxifier glyoxalase 1 (GLO1) in living systems is critical for understanding their roles in tumor initiation and progression. To date, the in situ fluorescence detection of… read more here.
Keywords: fluorescent probe; imaging tumorous; probe; fluorescent ... See more keywords
Assessment of a glyoxalase I frameshift variant, p.P122fs, in Japanese patients with schizophrenia
Sign Up to like & getrecommendations! Published in 2018 at "Psychiatric Genetics"
DOI: 10.1097/ypg.0000000000000204
Abstract: Enhanced carbonyl stress has been observed in a subgroup of patients with schizophrenia. Glyoxalase I, which is encoded by GLO1, is an enzyme that protects against carbonyl stress. In this study, we focused on the… read more here.
Keywords: glyoxalase; patients schizophrenia; variant p122fs; glo1 ... See more keywords
Protocatechualdehyde attenuates oxidative stress in diabetic cataract via GLO1-mediated inhibition of AGE/RAGE glycosylation
Sign Up to like & getrecommendations! Published in 2025 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2025.1586173
Abstract: Background Protocatechualdehyde (PCA), a phenolic compound derived from Salvia miltiorrhiza, exhibits anti-proliferative and antioxidant properties. However, its molecular mechanisms in reducing oxidative stress in diabetic cataract (DC) remain unclear. This study systematically investigated the role… read more here.
Keywords: glo1; age; oxidative stress; age rage ... See more keywords
Deleterious Effect of Advanced CKD on Glyoxalase System Activity not Limited to Diabetes Aetiology
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms19051517
Abstract: Methylglyoxal production is increased in diabetes. Methylglyoxal is efficiently detoxified by enzyme glyoxalase 1 (GLO1). The aim was to study the effect of diabetic and CKD milieu on (a) GLO1 gene expression in peripheral blood… read more here.
Keywords: glyoxalase system; gene expression; glo1; glo1 activity ... See more keywords
Butyrate increases methylglyoxal production through regulation of the JAK2/Stat3/Nrf2/Glo1 pathway in castration‑resistant prostate cancer cells
Sign Up to like & getrecommendations! Published in 2024 at "Oncology Reports"
DOI: 10.3892/or.2024.8730
Abstract: Cancer cells are characterized by increased glycolysis, known as the Warburg effect, which leads to increased production of cytotoxic methylglyoxal (MGO) and apoptotic cell death. Cancer cells often activate the protective nuclear factor erythroid 2-related… read more here.
Keywords: cancer cells; nrf2 glo1; glo1; stat3 ... See more keywords