Analytical comparability demonstrated for an IgG4 molecule, inclacumab, following transfer of manufacturing responsibility from Roche to Global Blood Therapeutics
Sign Up to like & getrecommendations! Published in 2022 at "Expert Opinion on Biological Therapy"
DOI: 10.1080/14712598.2022.2143260
Abstract: ABSTRACT Background Inclacumab is a recombinant, fully human, immunoglobulin IgG4 monoclonal antibody that selectively binds to P-selectin. Initially discovered and developed by Roche through phase 2 clinical studies in peripheral arterial disease and coronary artery… read more here.
Keywords: analytical comparability; roche; inclacumab; global blood ... See more keywords
The Not-So-Global Blood Oxygen Level-Dependent Signal
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DOI: 10.1089/brain.2017.0517
Abstract: Global signal regression is a controversial processing step for resting-state functional magnetic resonance imaging, partly because the source of the global blood oxygen level-dependent (BOLD) signal remains unclear. On the one hand, nuisance factors such… read more here.
Keywords: global signal; level dependent; signal; global blood ... See more keywords
Pharmacological Increase of Hb-O2 Affinity with a Voxelotor Analog Does Not Decrease Brain Tissue pO2 or Limit O2 Extraction in Brain Tissues of Sickle Cell Mice
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DOI: 10.1182/blood-2019-129282
Abstract: Sickle Cell Disease (SCD) is characterized by hemolytic anemia, vaso-occlusion, and progressive end-organ damage. The underlying mechanism of SCD is the polymerization of sickle hemoglobin (HbS) that occurs when sickle erythrocytes (SS RBCs) are partially… read more here.
Keywords: affinity; tissue; global blood; blood therapeutics ... See more keywords