Five Easy Metrics of Data Quality for LC-MS Based Global Metabolomics.
Sign Up to like & getrecommendations! Published in 2020 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.0c01493
Abstract: Data quality in global metabolomics is of great importance for biomarker discovery and systems biology studies. However, comprehensive metrics and methods to evaluate and compare the data quality of global metabolomics data sets are lacking.… read more here.
Keywords: quality; quality global; five easy; data quality ... See more keywords
Assessing Dietary Pesticide Intake and Potential Health Effects: The Application of Global Metabolomics Analysis.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.1c08050
Abstract: Scientific information is not yet available to provide insight into how individual metabolome might be affected by the presence of pesticides in regular diets. This study aimed to evaluate the perturbation of metabolomic pathways in… read more here.
Keywords: pesticide intake; global metabolomics; dietary pesticide; metabolomics analysis ... See more keywords
Sensitive quantification of short-chain fatty acids combined with global metabolomics in microbiome cultures.
Sign Up to like & getrecommendations! Published in 2023 at "Chemical communications"
DOI: 10.1039/d3cc01223a
Abstract: The microbiome has been identified to have a key role for the physiology of their human host. One of the major impacts is the clearance of bacterial pathogens. We have now developed a chemoselective probe… read more here.
Keywords: chain fatty; quantification short; fatty acids; global metabolomics ... See more keywords
Identification of potential plasma biomarkers and metabolic dysfunction for unstable angina pectoris and its complication based on global metabolomics
Sign Up to like & getrecommendations! Published in 2019 at "Bioscience Reports"
DOI: 10.1042/bsr20181658
Abstract: Unstable angina pectoris (UA) is one of the most dangerous clinical symptoms of acute coronary syndrome due to the risk of myocardial ischemia, which can lead to high morbidity and mortality worldwide. Though there are… read more here.
Keywords: global metabolomics; unstable angina; angina pectoris; potential plasma ... See more keywords
Comprehensive investigation of pathway enrichment methods for functional interpretation of LC-MS global metabolomics data
Sign Up to like & getrecommendations! Published in 2022 at "Briefings in bioinformatics"
DOI: 10.1093/bib/bbac553
Abstract: BACKGROUND Global or untargeted metabolomics is widely used to comprehensively investigate metabolic profiles under various pathophysiological conditions such as inflammations, infections, responses to exposures or interactions with microbial communities. However, biological interpretation of global metabolomics… read more here.
Keywords: enrichment methods; metabolomics data; pathway enrichment; functional interpretation ... See more keywords
Global Metabolomics Discovers Two Novel Biomarkers in Pyridoxine-Dependent Epilepsy Caused by ALDH7A1 Deficiency
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms232416061
Abstract: Pyridoxine-dependent epilepsy (PDE) is a rare autosomal recessive developmental and epileptic encephalopathy caused by pathogenic variants in the ALDH7A1 gene (PDE-ALDH7A1), which mainly has its onset in neonates and infants. Early diagnosis and treatment are… read more here.
Keywords: novel biomarkers; dependent epilepsy; pde aldh7a1; global metabolomics ... See more keywords
Comprehensive Meta-Analysis of COVID-19 Global Metabolomics Datasets
Sign Up to like & getrecommendations! Published in 2021 at "Metabolites"
DOI: 10.3390/metabo11010044
Abstract: The novel coronavirus SARS-CoV-2 has spread across the world since 2019, causing a global pandemic. The pathogenesis of the viral infection and the associated clinical presentations depend primarily on host factors such as age and… read more here.
Keywords: metabolomics datasets; comprehensive meta; meta; global metabolomics ... See more keywords