MIG1 as a positive regulator for the histidine biosynthesis pathway and as a global regulator in thermotolerant yeast Kluyveromyces marxianus
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DOI: 10.1038/s41598-019-46411-5
Abstract: Kmmig1 as a disrupted mutant of MIG1 encoding a regulator for glucose repression in Kluyveromyces marxianus exhibits a histidine-auxotrophic phenotype. Genome-wide expression analysis revealed that only HIS4 in seven HIS genes for histidine biosynthesis was… read more here.
Keywords: kluyveromyces marxianus; regulator; histidine biosynthesis; global regulator ... See more keywords
Identification of the RNA-binding domain-containing protein RbpA that acts as a global regulator of the pathogenicity of Streptococcus suis serotype 2
Sign Up to like & getrecommendations! Published in 2022 at "Virulence"
DOI: 10.1080/21505594.2022.2103233
Abstract: ABSTRACT Streptococcus suis serotype 2 (SS2), an emerging zoonotic pathogen, causes swine diseases and human cases of streptococcal toxic shock syndrome. RNA-binding proteins (RBPs) can modulate gene expression through post-transcriptional regulation. In this study, we… read more here.
Keywords: rna binding; suis serotype; pathogenicity; streptococcus suis ... See more keywords
The global regulator SpoVG modulates Staphylococcus aureus virulence through Agr-dependent pathways
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DOI: 10.1080/21505594.2025.2561827
Abstract: ABSTRACT Staphylococcus aureus (S. aureus) is a major pathogen responsible for a wide range of infections in both community and healthcare settings. Its virulence is orchestrated by a complex regulatory network. SpoVG, a global regulator… read more here.
Keywords: global regulator; aureus virulence; virulence; staphylococcus aureus ... See more keywords
Flagellar Assembly Factor FliW2 De‐Represses Helicobacter pylori FlaA‐Mediated Motility by Allosteric Obstruction of Global Regulator CsrA
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DOI: 10.1111/hel.70019
Abstract: Helicobacter pylori colonizes the human stomach as a dominant member of the gastric microbiota and constitutively expresses flagellar motility for survival. Carbon storage regulator A (CsrA) is a posttranscriptional global regulator and a critical determinant… read more here.
Keywords: motility; regulator csra; global regulator; csra ... See more keywords
Identification of a global regulator and its involvement in the regulation network of rubber degradation in Gordonia polyisoprenivorans VH2.
Sign Up to like & getrecommendations! Published in 2020 at "Applied and environmental microbiology"
DOI: 10.1128/aem.00774-20
Abstract: A cAMP receptor protein (CRPVH2) was detected as global regulator in Gordonia polyisoprenivorans VH2 and was supposed to participate in the network regulating poly(cis-1,4-isoprene) degradation as novel key regulator. CRPVH2 shares a sequence identity of… read more here.
Keywords: global regulator; regulation; rubber; crpvh2 ... See more keywords
Mutation of MtrA at the Predicted Phosphorylation Site Abrogates Its Role as a Global Regulator in Streptomyces venezuelae
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DOI: 10.1128/spectrum.02131-21
Abstract: Although phosphorylation has been shown to be essential for the activation of many response regulator proteins of two-component systems, the role of the phosphorylation site in the function of the global regulator MtrA in the… read more here.
Keywords: mtra; site; phosphorylation; global regulator ... See more keywords
The Global Regulator VeA Modulates ATP Sulfurylase to Mediate Adenosine Synthesis Resulting in Inhibitory Activity of Endophytic Fusarium solani against A549 Cells
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DOI: 10.17576/jsm-2025-5402-12
Abstract: Adenosine is an endogenous nucleoside that promotes apoptosis in cancer cells. Overexpression of the global regulator VeA gene (FsveA) in Fusarium solani resulted in the accumulation of multiple secondary metabolites, including adenosine. In this study,… read more here.
Keywords: solani; adenosine; global regulator; adenosine synthesis ... See more keywords
Overexpression of Global Regulator SCrp Leads to the Discovery of New Angucyclines in Streptomyces sp. XS-16
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DOI: 10.3390/md21040240
Abstract: Six angucyclines including three unreported compounds (1–3) were isolated from Streptomyces sp. XS-16 by overexpressing the native global regulator of SCrp (cyclic AMP receptor). The structures were characterized based on nuclear magnetic resonance (NMR) and… read more here.
Keywords: regulator scrp; scrp leads; leads discovery; global regulator ... See more keywords
Polyamine Induction of Secondary Metabolite Biosynthetic Genes in Fungi Is Mediated by Global Regulator LaeA and α-NAC Transcriptional Coactivator: Connection to Epigenetic Modification of Histones
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DOI: 10.3390/molecules30193903
Abstract: Polyamines are polycationic compounds present in all living cells that exert functions at different levels in the metabolism. They bind to DNA and RNA and modulate DNA replication and gene expression. Some of these regulatory… read more here.
Keywords: nac transcriptional; global regulator; epigenetic modification; secondary metabolite ... See more keywords