Loss of alpha‐globin genes in human subjects is associated with improved nitric oxide‐mediated vascular perfusion
Sign Up to like & getrecommendations! Published in 2020 at "American Journal of Hematology"
DOI: 10.1002/ajh.26058
Abstract: Alpha thalassemia is a hemoglobinopathy due to decreased production of the α‐globin protein from loss of up to four α‐globin genes, with one or two missing in the trait phenotype. Individuals with sickle cell disease… read more here.
Keywords: globin genes; globin; human subjects; globin gene ... See more keywords
Accurate detection of α-globin gene copy number variants with two reactions using droplet digital PCR.
Sign Up to like & getrecommendations! Published in 2022 at "Hematology"
DOI: 10.1080/16078454.2022.2030885
Abstract: BACKGROUND The α-thalassemia is a highly prevalent disease in tropical and subtropical regions, including southern China, and is mainly caused by deletion in α-globin genes (HBA1 and HBA2). The clinical manifestation of α-thalassemia is highly… read more here.
Keywords: copy number; number variants; globin genes; number ... See more keywords
Hematological and genetic profiles of persons with co‐inherited heterozygous β‐thalassemia and supernumerary α‐globin genes
Sign Up to like & getrecommendations! Published in 2023 at "European Journal of Haematology"
DOI: 10.1111/ejh.13923
Abstract: Thalassemias are common monogenic autosomal recessive hemoglobin disorders. The usually asymptomatic heterozygotes (β‐thalassemia traits, βTT) may rarely develop non‐transfusion‐dependent‐thalassemia (NTDT) due to co‐inheritance of supernumerary α‐globin genes. Literature on phenotypic/genotypic features of these rare combinations… read more here.
Keywords: globin genes; genetic profiles; supernumerary globin; hematological genetic ... See more keywords
A Novel Lncrna, Lncery, Interacts with Wdr82 to Regulate Erythroid Differentiation By Promoting Globin Gene Transcription
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DOI: 10.1182/blood-2020-139258
Abstract: Hematopoietic differentiation is controlled by both genetic and epigenetic regulators. Long non-coding RNAs (lncRNAs) have been demonstrated to be important for normal hematopoiesis, but their function in erythropoiesis needs to be further explored. Here, we… read more here.
Keywords: differentiation; erythroid differentiation; novel lncrna; lncery ... See more keywords
An intergenic non-coding RNA promoter required for histone modifications in the human β-globin chromatin domain
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DOI: 10.1371/journal.pone.0217532
Abstract: Transcriptome analyses show a surprisingly large proportion of the mammalian genome is transcribed; much more than can be accounted for by genes and introns alone. Most of this transcription is non-coding in nature and arises… read more here.
Keywords: globin genes; adult; globin; non coding ... See more keywords