A β-Globin Locus-Intrinsic Epigenetic Mechanism Underlies Fetal Globin Production in F-Cells
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DOI: 10.1182/blood-2020-137646
Abstract: Upregulation of fetal hemoglobin (HbF, α2γ2) by reversing the developmental switch to adult HbA (α2β2) is a key approach for both pharmacologic and gene targeting therapies in the treatment of sickle cell disease (SCD) and… read more here.
Keywords: adult; fetal globin; globin locus; expression ... See more keywords