Crystal structures of Uso1 membrane tether reveal an alternative conformation in the globular head domain
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-66480-1
Abstract: Membrane tethers play a critical role in organizing the complex molecular architecture of eukaryotic cells. Uso1 (yeast homolog of human p115) is essential for tethering in vesicle transport from ER to Golgi and interacts with… read more here.
Keywords: structures uso1; head domain; crystal structures; domain ... See more keywords
The Uso1 globular head interacts with SNAREs to maintain viability even in the absence of the coiled-coil domain.
Sign Up to like & getrecommendations! Published in 2023 at "eLife"
DOI: 10.7554/elife.85079
Abstract: Uso1/p115 and RAB1 tether ER-derived vesicles to the Golgi. Uso1/p115 contains a globular-head-domain (GHD), a coiled-coil (CC) mediating dimerization/tethering and a C-terminal region (CTR) interacting with golgins. Uso1/p115 is recruited to vesicles by RAB1. Genetic… read more here.
Keywords: rab1; e6k g540s; domain; ghd ... See more keywords