Intracellular transcytosis of albumin in glomerular endothelial cells after endocytosis through caveolae
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DOI: 10.1002/jcp.25817
Abstract: We previously described albumin endocytosis through caveolae in human renal glomerular endothelial cells (HRGECs). This suggested a new albumin transcytosis pathway, in addition to the fenestral pathway. As a next step, we investigated albumin transcytosis… read more here.
Keywords: caveolae; glomerular endothelial; endocytosis; endothelial cells ... See more keywords
Glomerular endothelial cells versus podocytes as the cellular target in diabetic nephropathy
Sign Up to like & getrecommendations! Published in 2018 at "Acta Diabetologica"
DOI: 10.1007/s00592-018-1211-2
Abstract: It usually takes several years (in some cases, decades) for predisposed individuals to move from the onset of type 1 or type 2 diabetes to the development of microalbuminuria, the first sign of diabetic nephropathy.… read more here.
Keywords: glomerular endothelial; target; diabetic nephropathy; endothelial cells ... See more keywords
Glomerular endothelial expression of type I IFN-stimulated gene, DExD/H-Box helicase 60 via toll-like receptor 3 signaling: possible involvement in the pathogenesis of lupus nephritis
Sign Up to like & getrecommendations! Published in 2022 at "Renal Failure"
DOI: 10.1080/0886022x.2022.2027249
Abstract: Abstract Background Sustained type I interferon (IFN) activation via Toll-like receptor (TLR) 3, 7 and 9 signaling has been reported to play a pivotal role in the development of lupus nephritis (LN). Although type I… read more here.
Keywords: via toll; glomerular endothelial; expression; ifn ... See more keywords
Klotho attenuates diabetic nephropathy in db/db mice and ameliorates high glucose-induced injury of human renal glomerular endothelial cells
Sign Up to like & getrecommendations! Published in 2019 at "Cell Cycle"
DOI: 10.1080/15384101.2019.1580495
Abstract: ABSTRACT Glomerular endothelial cell injury plays an important role in the development and progression of diabetic nephropathy (DN). The expression and function of klotho in glomerular endothelial cells remain unclear. Thus, this study aimed to… read more here.
Keywords: glomerular endothelial; diabetic nephropathy; endothelial cells; mice ... See more keywords
Glomerular deposition of galactose-deficient IgA1-containing immune complexes via glomerular endothelial cell injuries
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DOI: 10.1093/ndt/gfac204
Abstract: ABSTRACT Background Galactose-deficient immunoglobulin A1 (Gd-IgA1) plays a crucial role in the development of IgA nephropathy (IgAN). However, the pathological role of Gd-IgA1-containing immune complexes (ICs) and the mechanism of deposition in the mesangial region… read more here.
Keywords: iga1 containing; glomerular endothelial; deposition; endothelial cell ... See more keywords
The Role of Caveolae on Albumin Passage through Glomerular Endothelial and Epithelial Cells: The New Etiology of Urinary Albumin Excretion.
Sign Up to like & getrecommendations! Published in 2018 at "Contributions to nephrology"
DOI: 10.1159/000486929
Abstract: BACKGROUND In the traditional theory of albuminuria, small amounts of albumin pass through the fenestrae in glomerular endothelial cells, then through the slit membrane in the gaps between foot processes of glomerular epithelial cells. In… read more here.
Keywords: endothelial epithelial; glomerular endothelial; epithelial cells; etiology ... See more keywords
Mineralocorticoid receptor antagonism in diabetes reduces albuminuria by preserving the glomerular endothelial glycocalyx
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DOI: 10.1172/jci.insight.154164
Abstract: The glomerular endothelial glycocalyx (GEnGlx) forms the first part of the glomerular filtration barrier. Previously, we showed that mineralocorticoid receptor (MR) activation caused GEnGlx damage and albuminuria. In this study, we investigated whether MR antagonism… read more here.
Keywords: antagonism; glomerular endothelial; genglx; mineralocorticoid receptor ... See more keywords
Progenitor Renin Lineage Cells are not involved in the regeneration of glomerular endothelial cells during experimental renal thrombotic microangiopathy
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DOI: 10.1371/journal.pone.0196752
Abstract: Endothelial cells (EC) frequently undergo primary or secondary injury during kidney disease such as thrombotic microangiopathy or glomerulonephritis. Renin Lineage Cells (RLCs) serve as a progenitor cell niche after glomerular damage in the adult kidney.… read more here.
Keywords: glomerular endothelial; rlcs; regeneration; renin ... See more keywords
Laminar flow substantially affects the morphology and functional phenotype of glomerular endothelial cells
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DOI: 10.1371/journal.pone.0251129
Abstract: Shear stress induced by laminar blood flow has a profound effect on the morphology and functional phenotype of macrovascular endothelial cells. The influence of laminar flow on the glomerular microvascular endothelium, however, remains largely elusive.… read more here.
Keywords: phenotype; glomerular endothelial; endothelial cells; laminar flow ... See more keywords
Roles of glomerular endothelial hyaluronan in the development of proteinuria
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DOI: 10.14814/phy2.15019
Abstract: Vascular endothelial cells are covered with glycocalyx comprising heparan sulfate, hyaluronan, chondroitin sulfate, and associated proteins. Glomerular endothelial glycocalyx is involved in protecting against induction of proteinuria and structural damage, but the specific components in… read more here.
Keywords: development proteinuria; glomerular endothelial; serum hyaluronan; hyaluronan ... See more keywords
Glomerular endothelial cell senescence drives age‐related kidney disease through PAI‐1
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DOI: 10.15252/emmm.202114146
Abstract: The mechanisms underlying the development of glomerular lesions during aging are largely unknown. It has been suggested that senescence might play a role, but the pathophysiological link between senescence and lesion development remains unexplained. Here,… read more here.
Keywords: glomerular endothelial; kidney; pai; senescence ... See more keywords