Potential Role and Limitations of Estimated Glomerular Filtration Rate Slope Assessment in Cardiovascular Trials: A Review.
Sign Up to like & getrecommendations! Published in 2022 at "JAMA cardiology"
DOI: 10.1001/jamacardio.2021.5151
Abstract: Importance Cardiovascular trials have traditionally been underpowered to assess advanced chronic kidney disease (CKD) outcomes, and when included as a secondary end point, trials have used progression of CKD as incidence of some variation of… read more here.
Keywords: glomerular filtration; slope; estimated glomerular; progression ... See more keywords
Updated US Prevalence Estimates for Chronic Kidney Disease Stage and Complications Using the New Race-Free Equation to Estimate Glomerular Filtration Rate
Sign Up to like & getrecommendations! Published in 2022 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2022.0460
Abstract: This cross-sectional study investigates US population changes in chronic kidney disease (CKD) G stage and 4 CKD-related complications, comparing the 2021 equation for estimating glomerular filtration rate with the 2009 equation, which included a race… read more here.
Keywords: filtration rate; glomerular filtration; equation; kidney disease ... See more keywords
Development and Validation of a Prediction Model for Future Estimated Glomerular Filtration Rate in People With Type 2 Diabetes and Chronic Kidney Disease
Sign Up to like & getrecommendations! Published in 2023 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2023.1870
Abstract: Key Points Question Can routinely available data from primary care visits be used to develop and externally validate a prediction model that reliably predicts estimated glomerular filtration rate (eGFR) for upcoming follow-up visits? Findings In… read more here.
Keywords: glomerular filtration; prediction model; filtration rate; estimated glomerular ... See more keywords
Concordance and Discrepancies Among 5 Creatinine-Based Equations for Assessing Estimated Glomerular Filtration Rate in Older Adults
Sign Up to like & getrecommendations! Published in 2023 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2023.4211
Abstract: Key Points Question Can the 5 most common estimated glomerular filtration rate (eGFR) equations be used interchangeably among older adults? Findings In this cohort study including 3094 participants, different creatinine-based equations provided divergent estimates of… read more here.
Keywords: glomerular filtration; filtration rate; older adults; estimated glomerular ... See more keywords
Abemaciclib Inhibits Renal Tubular Secretion Without Changing Glomerular Filtration Rate
Sign Up to like & getrecommendations! Published in 2019 at "Clinical Pharmacology and Therapeutics"
DOI: 10.1002/cpt.1296
Abstract: Abemaciclib, an inhibitor of cyclin dependent kinases 4 and 6, is indicated for metastatic breast cancer treatment. Reversible increases in serum creatinine levels of ~15–40% over baseline have been observed following abemaciclib dosing. This study… read more here.
Keywords: filtration; glomerular filtration; abemaciclib inhibits; filtration rate ... See more keywords
Early changes in estimated glomerular filtration rate post‐initiation of empagliflozin in EMPEROR‐Reduced
Sign Up to like & getrecommendations! Published in 2022 at "European Journal of Heart Failure"
DOI: 10.1002/ejhf.2578
Abstract: Sodium–glucose cotransporter 2 inhibitors (SGLT2i) may induce an early post‐initiation decrease of estimated glomerular filtration rate (eGFR), which does not impact the SGLT2i benefits. The occurrence, characteristics, determinants, and clinical significance of an initial eGFR… read more here.
Keywords: glomerular filtration; filtration rate; estimated glomerular; post initiation ... See more keywords
Does “Birth” as an Event Impact Maturation Trajectory of Renal Clearance via Glomerular Filtration? Reexamining Data in Preterm and Full‐Term Neonates by Avoiding the Creatinine Bias
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Clinical Pharmacology"
DOI: 10.1002/jcph.1725
Abstract: Glomerular filtration rate (GFR) is an important measure of renal function. Various models for its maturation have recently been compared; however, these have used markers, which are subject to different renal elimination processes. Inulin clearance… read more here.
Keywords: term; gfr; age; birth ... See more keywords
Effect of weight loss on the estimated glomerular filtration rates of obese patients at risk of chronic kidney disease: the RIGOR‐TMU study
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cachexia, Sarcopenia and Muscle"
DOI: 10.1002/jcsm.12423
Abstract: Weight‐reduction therapies, including bariatric surgery (BS), are standard treatments for severely obese patients with type 2 diabetes; however, the outcomes of these therapies are inconclusive for obese patients with chronic kidney disease (CKD). This study… read more here.
Keywords: estimated glomerular; chronic kidney; obese patients; glomerular filtration ... See more keywords
Comment on the paper ‘Prospective pediatric study comparing glomerular filtration rate estimates based on motion-robust dynamic contrast-enhanced magnetic resonance imaging and serum creatinine (eGFR) to 99mTc DTPA’
Sign Up to like & getrecommendations! Published in 2020 at "Pediatric Radiology"
DOI: 10.1007/s00247-020-04890-z
Abstract: Dear Editors, I would like to comment on the paper “Prospective pediatric study comparing glomerular filtration rate estimates based on motion-robust dynamic contrastenhanced magnetic resonance imaging and serum creatinine (eGFR) to 99mTc DTPA,” by Kurugol… read more here.
Keywords: 99mtc dtpa; glomerular filtration; filtration rate; gfr ... See more keywords
Mutations in the heparan sulfate backbone elongating enzymes EXT1 and EXT2 have no major effect on endothelial glycocalyx and the glomerular filtration barrier
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Genetics and Genomics"
DOI: 10.1007/s00438-022-01854-w
Abstract: In this study, the effect of heterozygous germline mutations in the heparan sulfate (HS) glycosaminoglycan chain co-polymerases EXT1 and EXT2 on glomerular barrier function and the endothelial glycocalyx in humans is investigated. Heparan sulfate (HS)… read more here.
Keywords: glycocalyx; heparan sulfate; ext1 ext2; endothelial glycocalyx ... See more keywords
Variables of interest to predict glomerular filtration rate in preterm newborns in the first days of life
Sign Up to like & getrecommendations! Published in 2019 at "Pediatric Nephrology"
DOI: 10.1007/s00467-019-04257-z
Abstract: Background Measurement of neonatal renal function is challenging, and accurate, easy-to-use markers to estimate glomerular filtration rate (eGFR) are lacking. This study aimed to evaluate principal determinants of GFR in neonates and develop a predictive… read more here.
Keywords: glomerular filtration; life; filtration rate; clearance ... See more keywords